Search for dissertations about: "surface adhesin"

Showing result 21 - 25 of 39 swedish dissertations containing the words surface adhesin.

  2. 21. Identification and characterization of novel virulence factors in Streptococcus pneumoniae

    Author : Florian Wartha; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Streptococcus pneumoniae (the pneumococcus) is a major human pathogen with high morbidity and mortality worldwide. Increased antibiotic resistance and insufficient vaccination contribute to the re-emerging of this pathogen. READ MORE

  4. 22. Helicobacter pylori : molecular mechanisms for variable adherence properties

    Author : Anna Vallström; Anna Arnqvist; Kristian Riesbeck; Umeå universitet; []
    Keywords : H. pylori; adherence; BabA; SabA; Leb; sLex; phase variation; recombination; vesicles;

    Abstract : More than half of all people worldwide are infected with H. pylori. The infection always cause a gastric inflammation that may develop into peptic ulcer disease or gastric cancer. Attachment proteins, adhesins, mediate specific adherence of H. READ MORE

  5. 23. MORAXELLA CATARRHALIS OUTER MEMBRANE PROTEINS AND INTERACTIONS WITH THE HUMAN IMMUNE SYSTEM

    Author : Therése Nordström; Malmö Klinisk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mycology; Mikrobiologi; virology; Microbiology; C4BP; B-cells; UspA2; Moraxella catarrhalis; virologi; mykologi; bakteriologi; bacteriology; C3; IgD; Moraxella IgD-bindning protein; UspA1;

    Abstract : Moraxella catarrhalis is frequently colonizing the human respiratory tract, particularly in children. This gram-negative bacterium has during the last two decades been recognized as a pathogen causing otitis media in children and lower respiratory tract infections in adults with predisposing conditions such as chronic obstructive pulmonary disease (COPD). READ MORE

  6. 24. Lactobacilli expressing antibody fragments against pathogens

    Author : Anna Hultberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Adherence to mucosal surfaces has been shown to be of great importance in the pathogenesis of various infections in the gastro-intestinal tract. Live recombinant bacteria can be used to deliver active or passive immunity at the mucosal surface, which is the site of entry for the majority of the pathogens. READ MORE

  7. 25. Antiadhesive agents targeting uropathogenic Escherichia coli : Multivariate studies of protein-protein and protein-carbohydrate interactions

    Author : Andreas Larsson; Jan Kihlberg; Fredrik Almqvist; Mats Larhed; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Antibacterial; pili; antiadhesive agents; structure based design; statistical molecular design; 2-pyridone; amino acid derivative; galabiose; enaminone; SPR; ELISA; QSAR; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : This thesis describes studies directed towards development of novel antiadhesive agents, with particular emphasis on compounds that prevent attachment of bacteria to a host-cell. Three different proteins involved in the assembly or function of adhesive pili in uropathogenic Escherichia coli have been targeted either by rational structure based design or statistical molecular methods. READ MORE