Search for dissertations about: "surface-based biosensor"

Found 5 swedish dissertations containing the words surface-based biosensor.

2. 1. Towards specific quantification of exosomes using surface-based sensing

   Author : Deborah Rupert; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; label-free; surface plasmon resonance.; exosome; binding rate; antibody; concentration; nanoparticle tracking analysis; quantification; liposome; cluster of differentiation 63 CD63 ; diffusion; specific detection; mass transport limited conditions; extracellular vesicles; surface-based biosensor;

   Abstract : When exosomes were first observed in 1967, they were believed to be cell debris until extensive studies demonstrated key biological functionalities related to their composition and formation mechanism. Exosomes are nanometer-sized lipid vesicles of endocytic origin, with a membrane consisting of lipids and proteins and encapsulating a cargo composed of soluble proteins and genetic material. READ MORE

4. 2. Nanoplasmonic Biosensing - Exploring Unique Possibilities

   Author : Magnus Jonsson; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; biosensor; nanoholes; nanopores; nanofabrication; localized surface plasmon resonance; quartz crystal microbalance; nanoplasmonics; structural sensing; artificial cell membrane;

   Abstract : Bioanalytical sensors are indispensible tools in medical diagnostics and drug discovery as well as for life science research, environmental monitoring and food safety. In essence, they are used to detect and determine the concentrations of specific biomolecules in complex mixtures. READ MORE

5. 3. Waveguide Evanescent-Field Microscopy for Label-Free Monitoring of Biological Nanoparticles: Fabrication, Characterization and Application

   Author : Mokhtar Mapar; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biosensor; Protein interaction; Waveguide scattering microscopy; Waveguide fluorescence microscopy; Supported lipid bilayer; Image processing; Lipid vesicle; Nanofabrication; Exosome;

   Abstract : The recent development of microscopy methods, biological assays and bioanalytical sensors has significantly advanced the understanding of biological systems. Surface-based bioanalytical sensors have in recent years gained increased interest thanks to improvements in sensitivity and simplicity to use. READ MORE

6. 4. Lipid-Based Surface Modifications: towards the Development of Membrane-Protein Arrays

   Author : Indriati Pfeiffer; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; DNA-array; cholesterol-DNA; EIS; membrane proteins; lipid vesicles; QCM-D; supported lipid bilayer;

   Abstract : Mimics of the natural cell membrane, such as lipid vesicles and supported lipid membranes, have gained significant attention in recent years. This is primarily due to their ability to provide scientists with a model system allowing a large arsenal of scientific tools to be used in studies of biological reactions that are naturally controlled by the cell membrane and its components. READ MORE

7. 5. A Novel Route for Construction of Multipurpose Receptors through Chemical Modification of Glutathione Transferases

   Author : Johan Viljanen; Bengt Harald Jonsson; Kerstin Broo; Sophia Hober; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Human GST A1-1; site-specific covalent modification; tyrosine 9; lysine 216; methionine 208; multipurpose receptor; pattern recognition; protein purification; Chemistry; Kemi;

   Abstract : This thesis describes how the human Alpha class glutathione transferase (GST) A1-1 can be reprogrammed either to function as a multipurpose biosensor for detection of small molecule analytes, or as a handle providing for more efficient protein purification.A novel, user-friendly, and efficient method for site-specific introduction of functional groups into the active site of hGST A1-1 is the platform for these achievements. READ MORE