Search for dissertations about: "swi snf"
Showing result 1 - 5 of 16 swedish dissertations containing the words swi snf.
-
1. The SWI/SNF complex : Roles in transcription and pre-mRNA processing
Abstract : The regulation of gene expression is fundamental to the development of complex organisms and an important driving force in this process. When and where the genes are expressed decide the fate of a cell and its physiological context in the organism. READ MORE
-
2. Gene regulation by chromatin remodelling complexes : SWI/SNF complex in mRNA processing and B-WICH complex in ribosomal gene expression
Abstract : The aim of this project is to investigate the roles of chromatin remodelling complexes in gene regulation. It is focused on two groups of chromatin complexes: the mammalian BRG1 and BRM SWI/SNF complexes and the ISWI-containing B-WICH complex.Study 1 investigates the role of SWI/SNF complexes in alternative splicing. READ MORE
-
3. Chromatin Remodeling by BRG1 and SNF2H : Biochemistry and Function
Abstract : Chromatin is a highly dynamic, regulatory component in the process of transcription, repair, recombination and replication. The BRG1 and SNF2H proteins are ATP-dependent chromatin remodeling proteins that modulate chromatin structure to regulate DNA accessibility for DNA-binding proteins involved in these processes. READ MORE
-
4. Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3
Abstract : Chromosomal translocations leading to formation of tumor type specific fusion oncogenes are frequently found in human cancers. The FET family genes (FUS, EWSR1 and TAF15) occur in translocations with genes encoding various transcription factors in sarcomas and leukemias. READ MORE
-
5. FET fusion oncoproteins in sarcoma tumorigenesis - lnteractions with the SWI/SNF chromatin remodeling complex and epigenetic effects
Abstract : The FET family of fusion oncoproteins containing the N-terminal of either FUS, EWSR1 or TAF15 together with a transcription factor partner is the characteristic oncogenic driver of more than 20 types of sarcoma and leukemia, including myxoid liposarcoma and Ewing sarcoma. The FET oncoproteins are thought to function as aberrant transcription factors, however, the exact oncogenic mechanism remains to be elucidated. READ MORE