Search for dissertations about: "synaptic connectivity."

Showing result 1 - 5 of 31 swedish dissertations containing the words synaptic connectivity..

2. 1. Temporal dynamics of brain plasticity : characterizing brain structural changes during skill acquisition

   Author : Tomás Mediavilla; Daniel Marcellino; Alexandra Badea; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Motor learning; brain plasticity; structural plasticity; magnetic resonance imaging; voxel-based morphometry; tractography; connectivity; motor cortex; posterior parietal cortex; cerebellum; vesicular glutamate transporter;

   Abstract : Traditionally, structural plasticity in the human brain has been considered to follow a linear or asymptotic increase over the course of training. However, recent studies using structural MRI revealed transient increases in grey matter volume (GMV) with learning. READ MORE

4. 2. Model-Based Hypothesis Testing in Biomedicine : How Systems Biology Can Drive the Growth of Scientific Knowledge

   Author : Rikard Johansson; Gunnar Cedersund; Tomas Strömberg; Peter Strålfors; Marija Cvijovic; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; systems biology; modeling; ODE; hypothesis testing; falsificationism; insulin signaling; yeast; population heterogeneity; cell-to-cell variation; facilitation; pyramidal; synaptic; bootstrapping; personalized medicine; omics;

   Abstract : The utilization of mathematical tools within biology and medicine has traditionally been less widespread compared to other hard sciences, such as physics and chemistry. However, an increased need for tools such as data processing, bioinformatics, statistics, and mathematical modeling, have emerged due to advancements during the last decades. READ MORE

5. 3. Gene Therapy for Neurological Disorders

   Author : Jan Tönnesen; Lund Neurologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epileptiform activity; striatum; organotypic culture; electrophysiology; Wnt5a; synaptic connectivity.; cell transplantation; hippocampus; neural stem cells; epilepsy; functional integration; Parkinson’s disease; optogenetics; Gene therapy;

   Abstract : Gene therapy is an attractive strategy for neurological disorders, such as Parkinson’s disease and epilepsy, for several reasons. Introduction of genes with a therapeutic potential can be achieved locally, by accurate injections in the compromised tissue, and release of a transgene therapeutic substance can be regulated by the surrounding host neural circuitry. READ MORE

6. 4. Diversity of striatal interneurons : connectivity and functions

   Author : Anna Tokarska; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Multisensory integration of cortical and thalamic inputs by the striatal network, and its modulation by local acetylcholine and midbrain dopamine, are crucial components of movement control and striatal function. A flexible decision-making process, quick and smooth movement initiation, as well as proper habit-formation would not be possible without properly functioning striatal circuits. READ MORE

7. 5. Mapping brain circuits : anatomy, connectivity and function

   Author : Yang Xuan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : To decipher neural circuits anatomy is the central basis for all kinds of neurobiological studies. Here in this thesis, I will start with extensive overview of the current methods that have been intensively employed in labeling and mapping neurons and neuronal activities, including tracing techniques, imaging/recording systems and manipulation tools. READ MORE