Search for dissertations about: "systemic activity"
Showing result 1 - 5 of 369 swedish dissertations containing the words systemic activity.
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1. Systemic sclerosis : vascular, pulmonary and immunological aspects
Abstract : In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. READ MORE
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2. Studies on the deposition, bioavailability and systemic activity of glucocorticoids in man
Abstract : The local deposition, pharmacokinetics, and systemic activity of inhaled and intranasal glucocorticosteroids in different formulations and devices(ICSs) has been investigated. After nasal administration of the ICS budesonide (Bud), the systemic availability (F) was found to be significantly higher from an aqueous pump spray and from the powder inhaler Turbuhaler, than from a pressurized metered dose inhaler (pMDI), and the uptake process was slower and less complete with the pMDI formulation. READ MORE
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3. The Activity Diamond - Modeling an Enhanced Accessibility
Abstract : The purpose of the research presented in this thesis is to enhance the field of accessibility to include a multitude of perspectives. Based on cultural-historical activity theory (CHAT), it analyzes how human, artifactual and natural factors impact an individual’s possibilities to act in concrete situations that are part of a systemic whole. READ MORE
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4. Representing and Reasoning about Complex Human Activities - an Activity-Centric Argumentation-Based Approach
Abstract : The aim of this thesis is to develop theories and formal methods to endow a computing machinery with capabilities to identify, represent, reason and evaluate complex activities that are directed by an individual’s needs, goals, motives, preferences and environment, information which can be inconsistent and incomplete.Current methods for formalising and reasoning about human activity are typically limited to basic actions, e. READ MORE
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5. Non-symmetrical pregnane cyclic 16a, 17a-acetals and their C(22) epimers as anti-inflammatory agents : synthesis, structure and topical/systemic activity relationships
Abstract : .... READ MORE