Search for dissertations about: "tableting"

Showing result 1 - 5 of 9 swedish dissertations containing the word tableting.

2. 1. Interfacial and material aspects of powders with relevance to pharmaceutical tableting performance

   Author : Maria Badal Tejedor; Mark W. Rutland; William Ducker; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; atomic force microscopy; excipients; surface characterization; tableting; milling; amorphisation; Kemi; Chemistry;

   Abstract : Tablets are the most common forms of drug administration. They are convenient to administer and easy to manufacture. However, problems associated with the adhesion of the powders to the tableting tools are common. This phenomenon is known as sticking and even though it has been well documented and studied, it remains poorly understood. READ MORE

4. 2. Tableting performance of dry granulated particles : Significance and assessment of compression mechanical properties

   Author : Maryam Tofiq; Göran Alderborn; Ann-Sofie Persson; Josefina Nordström; Peter Kleinebudde; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dry granulation; Powder compression; Compression parameters; Granule composition; Granule structure; Granule strength; Granule fragmentation; Granule deformation; Tablet tensile strength; Loss of tabletability;

   Abstract : Dry granulation (DG) is often utilized as an intermediate process during tablet manufacturing, for improving flow characteristics of the powder blend and/or reducing segregation issues related to the active pharmaceutical ingredient (API). The resulting granules exhibit typically irregular shapes with rough surfaces and their mechanical properties are related to the feeding powder and the process parameters used during the DG. READ MORE

5. 3. Solid state characterisation and compaction behaviour of pharmaceutical materials

   Author : Christina Gustafsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; Solid-state; Tablet; Thermal analysis; Cellulose; Spectroscopy; NMR; NIR; FT-IR; Crystallinity; MVDA; FARMACI; PHARMACY; FARMACI; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

   Abstract : In this thesis, factors important in tableting operations and for tablet properties have been studied and characterised by different spectroscopic techniques as well as by some more conventionally used particle characterisation techniques. The spectroscopic techniques solid-state NMR, FT-IR and NIR spectroscopy, proved to be valuable tools in the estimation of particle and tablet properties, offering both specificity and sensitivity in the measurements. READ MORE

6. 4. Compression analysis as a tool for technical characterization and classification of pharmaceutical powders

   Author : Josefina Nordström; Göran Alderborn; Maria Strömme; Katharina Picker-Freyer; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; compaction; compression; granules; Kawakita; mechanical properties; particles; PAT; pharmaceutical powders; tablets; Pharmaceutics; Galenisk farmaci;

   Abstract : There are today strong incentives for an increased understanding of material properties and manufacturing processes to facilitate the development of new technologies in the pharmaceutical industry. The purpose of this thesis was to suggest methods requiring a low sample amount for characterization of technical properties of powders. READ MORE

7. 5. Relationship Between Crystal Structure and Mechanical Properties in Cocrystals and Salts of Paracetamol

   Author : Hamzah Ahmed; Ingvar Ymén; Luleå tekniska universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Health Science; Hälsovetenskap;

   Abstract : Oral tablets are convenient and widely administered drugdosage forms.The mechanical properties of a drug substance such as plasticity, ability to cohere into compacts and friction/adhesion are important in the development of a tablet formulation. READ MORE