Search for dissertations about: "tau protein"

Showing result 1 - 5 of 113 swedish dissertations containing the words tau protein.

  2. 1. Proximity Ligation Assay for High Performance Protein Analysis in Medicine

    Author : Gucci Jijuan Gu; Ulf Landegren; Thomas Joos; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein; post-translational modification; interactions; protein domain; western blotting; MARK; tau; AD; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : High quality reagents are preconditions for high performance protein analyses. But despite progress in some techniques, e.g. mass spectrometry, there is still a lack of affinity-based detection techniques with enhanced precision, specificity, and sensitivity. READ MORE

  4. 2. Diving and the brain

    Author : Anders Rosén; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; brain; central nervous system; decompression sickness; dive research; diving; neuronal damage; saturation diving; tau protein; venous gas embolism; neurofilament light; glial fibrillary acid protein; tau; VGE;

    Abstract : Abstract Introduction There are reports that long-term diving is associated with cognitive impairments. This raises the question if diving itself is harmful to the brain in the absence of decompression sickness or hypoxia. READ MORE

  5. 3. Proximity Ligation and Barcoding Assays : Tools for analysis of proteins and protein complexes

    Author : Di Wu; Masood Kamali-Moghaddam; Ulf Landegren; Ola Söderberg; Jörg Hoheisel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; proximity barcoding assay; sensitive; in situ; multiplex; profiling; amyloid-beta; MARK; tau; CSF; biomarker; protein complexes; Alzheimer’s disease; amyotrophic lateral sclerosis; Molekylär medicin; Molecular Medicine;

    Abstract : Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of proteins, such as by measuring their concentrations, characterizing their modifications, and detecting their interactions, provides insights in how biological systems work physiologically or pathologically at the molecular level. READ MORE

  6. 4. Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease

    Author : Erik Stomrud; Klinisk minnesforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cerebral blood flow; EEG; phosphorylated tau protein; amyloid beta protein; tau protein; cerebrospinal fluid; biomarkers; preclinical Alzheimer s disease; Alzheimer s disease; MCI; dementia; SPECT; memory; cognition; early diagnosis; control groups;

    Abstract : Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. READ MORE

  7. 5. Beta-amyloid, tau-protein and cystatin C in the pathophysiology of Alzheimer´s disease

    Author : Maj-Linda Selenica; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; neurophysiology; Neurology; Medicine human and vertebrates ; Medicin människa och djur ; Clinical chemistry; Klinisk kemi; Kinase inhibitors; Tau protein; Cystatin C; Glycogen Synthase Kinase; Alzheimers Disease; Amyloid beta;

    Abstract : Alzheimer´s Disease (AD) is a progressive neurodegenerative dementia characterized by the extracellular accumulation of the beta-amyloid (Ab) peptide into plaques and intracellular phosphorylation and accumulation of tau protein into neurofibrillary tangles (NFT). Inflammation due to astrocytic and microglial activation is one of the ongoing processes in the disease giving rise to cytokine production and oxidative stress. READ MORE