Search for dissertations about: "telomerase inhibitor"

Showing result 1 - 5 of 16 swedish dissertations containing the words telomerase inhibitor.

2. 1. Gene therapy tools: oligonucleotides and peptides

   Author : Jonas Eriksson; Ülo Langel; Jens Kurreck; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gene therapy; oligonucleotide; peptide; RNA-cleaving deoxyribozyme; deoxyribozyme; DNAzyme; cell-penetrating peptide; CPP; enzyme; enzyme kinetics; kinetic assay; assay; telomerase; telomerase inhibitor; imetelstat; GRN163L; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Abstract : Genetic mutations can cause a wide range of diseases, e.g. cancer. Gene therapy has the potential to alleviate or even cure these diseases. READ MORE

4. 2. Oesophageal Cancer – Novel Targets for Therapy : With focus on Hsp90, EGFR, LRIG, microtubule and telomerase

   Author : Xuping Wu; Simon Ekman; Johan Lennartsson; Ylva Pausson-Karlsson; Michael Bergqvist; Joachim Gullbo; Stefan Bergstöm; Gunilla Enblad; Claes Mercke; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hsp90; EGFR; LRIG; microtubule; telomerase; oesophageal cancer; imetelstat; DNA double-strand break; 17-AAG; radiation; prognosis; radiosensitisation; microtubule targeting agents; Oncology; Onkologi; Oncology; Onkologi;

   Abstract : Oesophageal cancer is a malignant and aggressive disease with very poor survival. The aim of this thesis was to evaluate novel therapeutic targets in oesophageal cancer. In paper I, Hsp90 was expressed in all 81 oesophageal cancer tissues and also in nine oesophageal cancer cell lines. READ MORE

5. 3. Signalling pathways in renal cell carcinoma with a focus on telomerase regulation

   Author : Raviprakash Tumkur Sitaram; Göran Roos; Anders Bjartell; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell carcinoma; DJ-1; NBS1; PTEN; WT1; cMyc; hTERT; telomerase; Pathology; Patologi; patologi; Pathology;

   Abstract : Telomerase is a ribonucleoprotein complex that catalyses telomeric repeat addition at the ends of chromosomes. The catalytic subunit, hTERT, acts as a key determinant for telomerase activity control; the induction of hTERT expression is required for telomerase activity. READ MORE

6. 4. Telomerase in hematological and other malignancies : therapeutic implications

   Author : Bingnan Li; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The Telomere is a nucleoprotein complex consisting of TTAGGG repeated sequences covered by specialized binding proteins termed shelterins masking the end of linear chromosomes and thereby protecting the end of the chromosome from genomic instability. Telomeres become progressively shortened during cellular replication and acts as a mitotic clock to confer a limited lifespan to normal cells. READ MORE

7. 5. Telomerase activation and its clinical implications in human thyroid tumors

   Author : Na Wang; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Telomerase is a ribonucleoprotein enzyme. The catalytic and rate-limiting component of telomerase is referred to as telomerase reverse transcriptase (TERT) that plays an important role in telomere maintenance, cell immortalization and malignant transformation. READ MORE