Search for dissertations about: "therapy interruption."
Showing result 1 - 5 of 11 swedish dissertations containing the words therapy interruption..
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1. Anti-CD20 therapy in multiple sclerosis : clinical and paraclinical outcomes
Abstract : Multiple sclerosis is a chronic inflammatory disease of the central nervous system and the most common non-traumatic cause of neurological disability in young adults. Rituximab is a B-cell depleting drug targeting the CD20 epitope on B-cells, which drive inflammation in relapsing-remitting multiple sclerosis by acting as antigen-presenting cells to activate T-cell responses against central nervous system autoantigens. READ MORE
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2. Studies on the efficacy of potent anti-HIV-1 therapy on virological and immunological factors
Abstract : The aim of this thesis was to assess to which extent treated human immunodeficiency virus type I (HIV-1) infected patients with a seemingly controlled, defined as undetectable plasma HIV-1 RNA levels (< 50 copies/ml), or low-grade viral replication, exhibited pattems in virological and immunological factors which could suggest a continuation of the disease process. We have therefore analysed the kinetics of HIV-1 DNA levels (Papers I and II), the viral evolution (Paper II), the changes in Beta-chemokine levels (Paper 111) and sCD27 levels (Paper IV), and the appearance of drug resistance associated mutations (Paper V) in such patients. READ MORE
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3. Studies on ribonucleotide reductase, a target for anticancer therapy, with focus on electron donor aspects : thioredoxin and glutaredoxin systems
Abstract : Faithful replication of DNA and its repair are fundamental processes in all living cells which utilize deoxyribonucleotides as DNA building blocks. Ribonucleotide reductase (RNR) is the essential enzyme for de novo synthesis of these precursors from ribonucleoside diphosphates. READ MORE
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4. HIV therapies : from health-related quality of life to DNA levels
Abstract : The treatment of people infected with HIV was revolutionised with the introduction of protease inhibitor based antiretroviral combination therapy. The therapy has greatly reduced the incidence of AIDS and AIDS-related mortality in the industrialised world. READ MORE
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5. Studies on medical and immunological intervention in HIV-1 infection
Abstract : The very first HIV-1 infected patients who received antiretroviral combination therapy (HAART) were severely ill and had very low CD4+ T cell counts. We describe a group of severely ill HIV- I infected patients monitored for the first two years of their HAART. READ MORE