Search for dissertations about: "thesis, anti diabetic"

Showing result 1 - 5 of 78 swedish dissertations containing the words thesis, anti diabetic.

  2. 1. Inflammatory mediators in diabetic retinopathy

    Author : Carin Gustavsson; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; dyslipidemia; diabetic retinopathy; oxidative stress; TNF-alpha; VCAM-1;

    Abstract : Diabetic retinopathy (DR) is the most feared complication of diabetes with an overall prevalence of 21.9-36.8% and may, if untreated, lead to severe visual disability or blindness. READ MORE

  4. 2. On anti-diabetic agents and the vasculature

    Author : Eva Linnéa Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Diabetes is rapidly increasing worldwide, and the number of patients suffering from diabetes is projected to rise with 50 % over the next 25 years, then affecting almost 600 million adults. Type 2 diabetes comprises 90-95 % of all people with diabetes, and they constitute a patient group that carries a high burden of cardiovascular disease. READ MORE

  5. 3. Anti-diabetic and anti-inflammatory effects of medicinal plants in a type 2 diabetic animal model

    Author : Ezarul Faradianna Lokman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Type 2 diabetes;

    Abstract : Medicinal plants have been suggested since ancient times to be a good source of drugs for treating diabetes. The aims of this thesis were to identify the anti-diabetic effects and to understand further the mechanisms involved for two traditional plants, borapetol B (C1) isolated from Tinospora crispa, and Gynostemma pentaphyllum (GP), in diabetic rats. READ MORE

  6. 4. Safety and Efficacy Modelling in Anti-Diabetic Drug Development

    Author : Bengt Hamrén; Mats O Karlsson; Eric Snoeck; Uppsala universitet; []
    Keywords : Pharmaceutical biosciences; pharmacokinetic; pharmacodynamic; mechanism-based; modelling; type 2 diabetes mellitus; tesaglitazar; PPAR; drug development; NONMEM; Farmaceutisk biovetenskap;

    Abstract : A central aim in drug development is to ensure that the new drug is efficacious and safe in the intended patient population. Mathematical models describing the pharmacokinetic-pharmacodynamic (PK-PD) properties of a drug are valuable to increase the knowledge about drug effects and disease and can be used to inform decisions. READ MORE

  7. 5. Anti-VEGF treatment of patients with diabetic macular edema : Studies of visual acuity, macular edema and patient-reported outcomes

    Author : Therese Granström; Janeth Leksell; Henrietta Forsman; Elisabet Granstam; Högskolan Dalarna; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hälsa och välfärd; Health and Welfare;

    Abstract : The aim of this thesis was to describe and evaluate visual acuity, macular edema and patientreported outcomes (PRO) following anti-VEGF treatment of diabetic macular edema (DME) patients in a real-world setting. Using a longitudinal study design, a cohort of DME patients was followed from baseline to 1 year after treatment start. READ MORE