Search for dissertations about: "thesis for breast cancer"

Showing result 1 - 5 of 312 swedish dissertations containing the words thesis for breast cancer.

  1. 1. High-risk breast cancer: From biology to personalized therapeutic strategies

    Author : Toshima Z Parris; Göteborgs universitet.; Gothenburg University.; Göteborgs universitet.; Gothenburg University.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; outcome prediction; molecular biomarker; 8p11-p12 amplification;

    Abstract : Adjuvant treatment regimens for breast cancer are primarily based on patient- and tumor-related factors, e.g. patient menopausal status, tumor stage and histological grade, and the status of molecular tumor markers (HER2/neu and the estrogen receptor). READ MORE

  2. 2. Molecular Cytogenetics in Sporadic Breast Cancer

    University dissertation from Department of Oncology, Clinical Sciences, Lund University

    Author : Karin Rennstam; Lunds universitet.; Lund University.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; onkologi; Cytology; Cytologi; cancer; gene expression; gene amplification; tumor development; cDNA microarray; fluorescence in situ hybridization FISH ; breast cancer; comparative genomic hybridization CGH ; cancerology; ERBB2;

    Abstract : In recent time breast cancer has become the most common form of female cancer in the western world. It has been estimated that the lifetime risk of women falling ill from the disease is 10%. The number of patients diagnosed each year has been increasing steadily since the 1970s. READ MORE

  3. 3. Prostate cancer epidemiological studies of risk factors

    University dissertation from Umeå : Umeå universitet

    Author : Camilla Thellenberg Karlsson; Umeå universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; epidemiology; SNP; BRCA2; male breast cancer; inflammation; BPH; P53; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi;

    Abstract : In spite of the fact that prostate cancer is the most common male cancer in both Sweden and many other countries in the developed world, little is known of risk factors and predisposing conditions. The only well recognized risk factors are age, race and familial aggregation. READ MORE

  4. 4. Predictive markers for tamoxifen response in primary breast cancer

    University dissertation from Lund University, Faculty of Medicine Doctoral Dissertation Series

    Author : Maria Stendahl; Lunds universitet.; Lund University.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General pathology; cancer; Cytologi; onkologi; prognosis; Cytology; oncology; cancerology; predictive marker; p27; cyclin D1; tamoxifen; PR; breast cancer; ER; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Abstract : It is well-known that a majority of breast cancers are hormone-dependent, making endocrine therapy an important adjuvant treatment after surgery. Susceptibility to endocrine treatment is determined by the presence of estrogen receptors (ER) and progesterone receptors (PR) in the tumors. READ MORE

  5. 5. Functional and Molecular Characterization of BRCA1 and BRCA2 Associated Breast Cancer

    University dissertation from KFS AB

    Author : Johan Vallon-Christersson; Lunds universitet.; Lund University.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; onkologi; Cytologi; cancerology; Cytology; BioArray Software Environment; BASE; Software; Open-source; Copy number; Gene expression; Microarray; BRCA2; BRCA1; Breast cancer; Hereditary cancer; oncology;

    Abstract : This doctoral dissertation is based on five appended papers primarily concerned with three main topics, namely: the functional characterization of specific and clinically relevant perturbations found in BRCA1 ? one of the major breast cancer susceptibility genes; the use of microarray technologies for molecular characterization of hereditary breast tumor samples from a genomic perspective; and finally, the development of software to address some of the logistical problems of data analysis and management that arise when utilizing microarrays. Results obtained from the work presented herein demonstrate the following: that transcription az says can aid in the characterization of C-terminal missense mutations but that it may not be possible to unambiguously characterize variants with a yeast-based assay alone; that a naturally occurring C-terminal germline mutation in BRCA1 encodes a protein with apparent temperature-dependant functional properties; that open-source software can provide comprehensive solutions to meet data management needs of microarray experimenters; that BRCA1 and BRCA2 associated breast tumors exhibit markedly different copy number aberrations when compared to each other as well as to sporadic tumors; and that gene expression profiling in BRCA1 and BRCA2 associated breast tumors reveals specific gene expression patterns. READ MORE