Search for dissertations about: "thesis in TOXICOLOGY"

Showing result 1 - 5 of 208 swedish dissertations containing the words thesis in TOXICOLOGY.

  1. 1. Pluripotent Stem Cells of Embryonic Origin : Applications in Developmental Toxicology

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Måns Jergil; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; PHARMACY Toxicology; FARMACI Toxikologi; Toxikologi; Toxicology;

    Abstract : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. READ MORE

  2. 2. The Role of Chlamydia pneumoniae-induced Platelet Activation in Cardiovascular Disease : In vitro and In vivo studies

    University dissertation from Institutionen för medicin och vård

    Author : Hanna Kälvegren; Linköpings universitet.; Linköpings universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chlamydia pneumoniae; Platelet; atherosclerosis; Infection; LDL-oxidation; Percutaneous coronary intervention; Cardiovascular disease; Serotonin; Reactive oxygen species production; MEDICINE Physiology and pharmacology Pharmacological research Pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Farmakologi;

    Abstract : The common risk factors for atherosclerosis, such as obesity, high cholesterol levels, sedentary lifestyle, diabetes and high alcohol intake, only explain approximately 50% of cardiovascular disease events. It is thereby important to identify new mechanisms that can stimulate the process of atherosclerosis. READ MORE

  3. 3. Developmental Neurotoxicity Testing Using In vitro Approaches

    University dissertation from Stockholm : The Wenner-Gren Institute, Stockholm University

    Author : Helena Högberg; Stockholms universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE Physiology and pharmacology Pharmacological research Toxicology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Toxikologi; toxikologi; Toxicology;

    Abstract : There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. READ MORE

  4. 4. Transcriptomics and Proteomics Applied to Developmental Toxicology

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Kim Kultima; Uppsala universitet.; [2007]
    Keywords : Toxicology; 2D-DIGE; Valproic acid; PBDE-99; Flame retardant; Neural tube defects; Microarray; In vivo; In vitro; Biomarker; Brain growth spurt; Normalization; Mouse embryo; Toxicogenomics; Toxikologi;

    Abstract : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. READ MORE

  5. 5. Platelet Adhesion to Proteins in Microplates : Applications in Experimental and Clinical Research

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Andreas Eriksson; Linköpings universitet.; Linköpings universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelets; platelet adhesion; platelet assay; synergistic activation; thrombosis; anti-platelet treatment; MEDICINE Physiology and pharmacology Pharmacological research Pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Farmakologi;

    Abstract : Platelets are crucial for prevention of blood loss after vessel injury. Platelet adhesion to disrupted vessel walls is mediated by receptors such as the GPIb-IX-V complex that binds von Willebrand factor and the collagen-binding integrin α2β1. READ MORE