Search for dissertations about: "thesis in TOXICOLOGY"

Showing result 1 - 5 of 310 swedish dissertations containing the words thesis in TOXICOLOGY.

  1. 1. Pluripotent Stem Cells of Embryonic Origin : Applications in Developmental Toxicology

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Måns Jergil; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; PHARMACY Toxicology; FARMACI Toxikologi; Toxikologi; Toxicology;

    Abstract : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. READ MORE

  2. 2. Development of Methods for Assessing Unbound Drug Exposure in the Brain : In vivo, in vitro and in silico

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Markus Fridén; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Drug transport; Tissue distribution; Transporters; Pharmacokinetics; PHARMACY Other pharmacy; FARMACI Övrig farmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Abstract : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. READ MORE

  3. 3. The Role of Chlamydia pneumoniae-induced Platelet Activation in Cardiovascular Disease : In vitro and In vivo studies

    University dissertation from Institutionen för medicin och vård

    Author : Hanna Kälvegren; Linköpings universitet.; Linköpings universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chlamydia pneumoniae; Platelet; atherosclerosis; Infection; LDL-oxidation; Percutaneous coronary intervention; Cardiovascular disease; Serotonin; Reactive oxygen species production; MEDICINE Physiology and pharmacology Pharmacological research Pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Farmakologi;

    Abstract : The common risk factors for atherosclerosis, such as obesity, high cholesterol levels, sedentary lifestyle, diabetes and high alcohol intake, only explain approximately 50% of cardiovascular disease events. It is thereby important to identify new mechanisms that can stimulate the process of atherosclerosis. READ MORE

  4. 4. Inhibitory neurotransmission in lower oesophagus

    University dissertation from Divison of Clinical Chemistry and Pharmacology

    Author : Lars Ny; Lunds universitet.; Lund University.; [1996]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; farmaci; toxikologi; Farmakologi; farmakognosi; toxicology; pharmacy; pharmacognosy; pituitary adenylate cyclase activating peptide; vasoactive intestinal peptide; Pharmacological sciences; oesophagus; nonadrenergic noncholinergic; nitric oxide; lower oesophageal sphincter; haem oxygenase; cyclic GMP; carbon monoxide; cyclic AMP;

    Abstract : The inhibitory neuromuscular control of the human and cat lower oesophagus was investigated by morphological, functional, and biochemical methods. A supply of nerve fibres and myenteric cell bodies, containing nitric oxide synthase (NOS), haem oxygenase (HO)-2, vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase activating peptide (PACAP) was observed. READ MORE

  5. 5. Tissue-Selective Activation and Toxicity of Substituted Dichlorobenzenes : Studies on the Mechanism of Cell Death in the Olfactory Mucosa

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Franzén; Uppsala universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; tissue-selective toxicity; bioactivation; olfactory mucosa; substituted dichlorobenzenes; Bowman s glands; sustentacular cells; ER stress; Grp78; caspase-12; caspase-3; CYP2A5; protein adduction; nasal toxicity; Toxikologi; PHARMACY Toxicology; FARMACI Toxikologi;

    Abstract : The nasal passages are constantly exposed to both air- and bloodborne foreign compounds. In particular, the olfactory mucosa is demonstrated to be susceptible to a variety of drugs and chemicals. READ MORE