Search for dissertations about: "thesis in TOXICOLOGY"

Showing result 1 - 5 of 261 swedish dissertations containing the words thesis in TOXICOLOGY.

  1. 1. Pluripotent Stem Cells of Embryonic Origin : Applications in Developmental Toxicology

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Måns Jergil; Uppsala universitet.; [2009]
    Keywords : Medical and Health Sciences Basic Medicine Pharmacology and Toxicology; Medicin och hälsovetenskap Medicinska grundvetenskaper Farmakologi och toxikologi; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; PHARMACY Toxicology; FARMACI Toxikologi; Toxikologi; Toxicology;

    Abstract : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. READ MORE

  2. 2. Transcriptomics and Proteomics Applied to Developmental Toxicology

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Kim Kultima; Uppsala universitet.; [2007]
    Keywords : Toxicology; 2D-DIGE; Valproic acid; PBDE-99; Flame retardant; Neural tube defects; Microarray; In vivo; In vitro; Biomarker; Brain growth spurt; Normalization; Mouse embryo; Toxicogenomics; Toxikologi;

    Abstract : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. READ MORE

  3. 3. Development of Methods for Assessing Unbound Drug Exposure in the Brain : In vivo, in vitro and in silico

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Markus Fridén; Uppsala universitet.; [2010]
    Keywords : Medical and Health Sciences Basic Medicine Pharmaceutical Sciences; Medicin och hälsovetenskap Medicinska grundvetenskaper Farmaceutisk vetenskap; Medical and Health Sciences Basic Medicine Pharmaceutical Sciences; Medicin och hälsovetenskap Medicinska grundvetenskaper Farmaceutisk vetenskap; Medical and Health Sciences Basic Medicine Pharmacology and Toxicology; Medicin och hälsovetenskap Medicinska grundvetenskaper Farmakologi och toxikologi; Blood-brain barrier; Drug transport; Tissue distribution; Transporters; Pharmacokinetics; PHARMACY Other pharmacy; FARMACI Övrig farmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Abstract : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. READ MORE

  4. 4. Zopiclone degradation in biological samples : Characteristics and consequences in forensic toxicology

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Gunnel Nilsson; Linköpings universitet.; Linköpings universitet.; [2014]
    Keywords : Medical and Health Sciences; Medicin och hälsovetenskap;

    Abstract : Bio-analytical results are influenced by in vivo factors such as genetics, pharmacological and physiological conditions and in vitro factors such as specimen composition, sample additives and storage conditions. Zopiclone (ZOP) is a short-acting hypnotic drug (Imovane®) used for treatment of insomnia. READ MORE

  5. 5. Interactions between cytochrome P450 and estrogenic compounds in fish

    University dissertation from University of Gothenburg

    Author : Linda Hasselberg; Göteborgs universitet.; University of Gothenburg.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biologi; Biology; Cell- och molekylärbiologi; Cell and molecular biology; Toxikologi; Toxicology; Cytochrome P450; CYP1A; CYP3A; glutathione; alkylphenols; ethynylestradiol; ketoconazole; vitellogenin; Atlantic cod; rainbow trout; fish;

    Abstract : DISSERTATION ABSTRACT Hasselberg, Linda. Interactions between cytochrome P450 and estrogenic compounds in fish. Department of Zoophysiology, Göteborg University, Box 463, SE-405 30 Göteborg, Sweden Contamination by various pollutions is an environmental concern. READ MORE