Search for dissertations about: "thesis in epigenetics of diabetes"

Showing result 1 - 5 of 12 swedish dissertations containing the words thesis in epigenetics of diabetes.

  2. 1. Study of DNA methylation in human pancreatic islets

    Author : Elin Hall; Diabetes - epigenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; epigenetics; DNA mehtylation; human pancreatic islets; insulin secretion;

    Abstract : Today type 2 diabetes is a common disease with a worldwide prevalence of 8.3%. The disease is characterised by hyperglycaemia which is a result of insufficient insulin secretion from the beta-cells in the pancreatic islets as well as an insulin resistance seen in the target tissues. READ MORE

  4. 2. The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes

    Author : Tina Rönn; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene expression; oxidative phosphorylation; GWAS; SNP; DNA methylation; epigenetics; type 2 diabetes;

    Abstract : The incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. READ MORE

  5. 3. Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans

    Author : Anders H Olsson; Diabetes - epigenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Genetics; Epigenetics; Human Pancreatic Islets; Oxidative Phosphorylation; Insulin Secretion;

    Abstract : The prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistance in peripheral tissues. READ MORE

  6. 4. The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes

    Author : Tasnim Dayeh; Diabetes - epigenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG-SNP; glucagon secretion; insulin secretion; human pancreatic islets; DNA methylation; Epigenetics;

    Abstract : Islet dysfunction is central to the development and progression of type 2 diabetes (T2D). Epigenetic modifications are essential for establishing and maintaining cell identity and function in normal circumstances. Exposure to adverse environmental factors may alter the epigenome, and result in changes of gene expression and the resulting phenotype. READ MORE

  7. 5. Studies of epigenetic deregulation in parathyroid tumors and small intestinal neuroendocrine tumors

    Author : Elham Barazeghi; Gunnar Westin; Peter Stålberg; Per Hellman; Christofer Juhlin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epigenetics; 5hmC; TET1; TET2; parathyroid tumors; SI-NET; RRBS; PTPRM;

    Abstract : Deregulation of the epigenome is associated with the initiation and progression of various types of human cancers. Here we investigated the level of 5-hydroxymethylcytosine (5hmC), expression and function of TET1 and TET2, and DNA methylation in parathyroid tumors and small intestinal neuroendocrine tumors (SI-NETs). READ MORE