Search for dissertations about: "thiopurine methyltransferase"
Showing result 1 - 5 of 8 swedish dissertations containing the words thiopurine methyltransferase.
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1. Pharmacogenetic studies of thiopurines : focus on thiopurine methyltransferase
Abstract : Pharmacogenetics represents the study ofvariability in drug response due to genetic variations. The thiopurines (6-mercaptopurine, 6-thioguanine and azathioprine) are prodrugs which require metabolic transformation to exert effect. READ MORE
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2. Biophysical Characterization of Thiopurine S-Methyltransferase : A Key enzyme in the Effects of Thiopurine Drugs
Abstract : In the treatment of leukemia and inflammatory bowel disease, thiopurines are commonly used drugs. Thiopurine S-methyltransferase (TPMT) is one of the drug metabolizing enzymes responsible of counteracting the formation of TGNs that will be incorporated into the DNA and RNA synthesis and thus induce apoptosis. READ MORE
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3. Clinical studies of thiopurine metabolism in inflammatory bowel disease
Abstract : Inflammatory bowel disease (IBD, i.e. primarily Crohn's disease and ulcerative colitis) is characterised by a chronic or relapsing inflammation of the digestive tract. READ MORE
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4. Thiopurine S-methyltransferase - characterization of variants and ligand binding
Abstract : Thiopurine S-methyltransferase (TPMT) belongs to the Class I S-adenosylmethionine-dependent methyltransferase (SAM-MT) super family of structurally related proteins. Common to the members of this large protein family is the catalysis of methylation reactions using S-adenosylmethionine (SAM) as a methyl group donor, although SAM-MTs act on a wide range of different substrates and carry out numerous biologically important functions. READ MORE
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5. Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism
Abstract : The thiopurines (6-mercaptopurine [6-MP], 6-thioguanine and azathioprine) are cytotoxic drugs used in the treatment of acute lymphoblastic leukemia (ALL), inflammatory bowel diseases, certain autoimmune diseases and after transplantation. The metabolism of thiopurines is complex with several enzymes involved in the conversion into active drug metabolites. READ MORE