Search for dissertations about: "thrombin time"

Showing result 1 - 5 of 43 swedish dissertations containing the words thrombin time.

  2. 1. Thrombin generation in different cohorts : Evaluation of the haemostatic potential

    Author : Roza Chaireti; Tomas Lindahl; Elvar Theodorsson; Sven Almer; Per Morten Sandset; Linköpings universitet; []
    Keywords : ;

    Abstract : The aim of this thesis is to evaluate thrombin generation in patients with thrombophilia (Paper I), in patients with venous thromboembolism (Paper II), in healthy women during the menstrual cycle (Paper III), in patients with liver disease (Paper IV) and in patients with mild deficiency of factor VII (Paper V).For this purpose, thrombin generation was measured in platelet poor plasma by the calibrated automated thrombogram (CAT®) assay. READ MORE

  4. 2. The Role of Innate Immunity in Islet Transplantation : Clinical and Experimental Studies

    Author : Lisa Moberg; Bo Nilsson; Olle Korsgren; Kristina Nilsson Ekdahl; Rolf Larsson; David Harlan; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; diabetes; islet transplantation; islet of Langerhans; coagulation activation; IBMIR; tissue factor; thrombin; inactivated FVIIa; melagatran; neutrophilic granulocyte; Immunologi; Immunology; Immunologi;

    Abstract : Clinical islet transplantation is an emerging procedure to cure type 1 diabetes. The graft is implanted by infusion into the liver through the portal vein. A major obstacle that still needs to be overcome is the requirement for islets from multiple donors to achieve insulin independence. READ MORE

  5. 3. Interactions between whole blood and biomaterial surfaces. With focus on the respiratory burst of adhering neutrophils as an early sign of cytotoxicity

    Author : Noushin Yahyapour; Göteborgs universitet; []
    Keywords : wettability; titanium; glass; peritoneal dialysis fluid; surface-adhering neutrophils; respiratory burst; thrombin; kallikrein; complement C5b-9;

    Abstract : Although a vast array of materials is used to augment or replace a natural function in the human body, many of them cause side-effects or may be rejected. The growing need for more biocompatible devices has been accompanied by an increase in new materials. READ MORE

  6. 4. Introducing weak affinity chromatography to drug discovery with focus on fragment screening

    Author : Minh-Dao Duong-Thi; Sten Ohlson; Brian Dymock; Linnéuniversitetet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affinity LC-MS; fragment-based drug discovery; fragment screening; high throughput; mass spectrometry; stereoisomer; enantiomer; thrombin; weak affinity chromatography; WAC; WAC-MS.; Biomedical Sciences; Biomedicinsk vetenskap; Biokemi; Biochemistry;

    Abstract : Fragment-based drug discovery is an emerging process that has gained popularity in recent years. The process starts from small molecules called fragments. One major step in fragment-based drug discovery is fragment screening, which is a strategy to screen libraries of small molecules to find hits. READ MORE

  7. 5. Progress of Weak Affinity Chromatography as a Tool in Drug Development

    Author : Elinor Meiby; Sten Ohlson; Manfred Raida; Linnéuniversitetet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; weak affinity chromatography; fragment based drug discovery; fragment screening; thrombin; trypsin; cyclin G-associated kinase; Hsp90; Pin1; cyclooxygenase; lipodisks; Biokemi; Biochemistry;

    Abstract : Weak Affinity Chromatography (WAC) is a technology that was developed to analyse weak (KD > 10-5 M) although selective interactions between biomolecules. The focus of this thesis was to develop this method for various applications in the drug development process.Fragment Based Drug Discovery is a new approach in finding new small molecular drugs. READ MORE