Search for dissertations about: "thymoma"

Showing result 1 - 5 of 10 swedish dissertations containing the word thymoma.

  2. 1. Myasthenia gravis : clinical aspects and possible involvement of prolactin

    Author : Natalia Tsinzerling; Karolinska Institutet; Karolinska Institutet; []
    Keywords : myasthenia gravis; prolactin; immune regulation; thymic pathology; thymoma; immunosuppressive treatment;

    Abstract : Myasthenia gravis (MG) is an autoimmune disease characterized by the production of antibodies against the skeletal muscle acetylcholine receptor (AChR). MG is usually associated with thymic disorders including thymoma (about 10%) and lymphofollicular hyperplasia (HPL) (up to 80%). READ MORE

  4. 2. Genetic and immunological control of human myasthenia gravis

    Author : Xiaoyan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myasthenia Gravis MG ; beta2-adrenergic receptor beta2-AR ; CCR2; CCR5; cytolytic T lymphocyte-associated antigen-4 CTLA-4 ; OX40;

    Abstract : Myasthenia gravis (MG) is a classical autoimmune disease characterized by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AChR) on the post-synaptic membrane of the neuromuscular junction. Because of the involvement of multiple factors in the disease, the overall aims of this thesis were to uncover the regulation of candidate genes and the possible cellular mechanisms involved in the immuno-regulation of human MG. READ MORE

  5. 3. Long-term prognostic and predictive factors in hormone receptor positive breast cancer

    Author : Helena Fohlin; Olle Stål; John Carstensen; Olsson Håkan; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The breast cancer survival in Sweden is good (almost 90 % 5-year relative survival) and has increased over time. For women with hormone receptor negative tumors, most relapses occur within the first 5 years after diagnosis. Thereafter the recurrence risk decreases rapidly. READ MORE

  6. 4. Studies of immune mechanisms in myasthenia gravis

    Author : Biying Xu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : myasthenia gravis; acetylcholine receptor; ß-adrenergic receptor; antibody; T cell receptor; antibody-dependent cell-mediated cytotoxicity; gene polymorphism;

    Abstract : Myasthenia gravis (MG) has been considered the prototype of autoantibody-mediated autoimmune diseases. The pathogenic autoantibodies are directed against the acetylcholine receptor (AChR). Several mechanisms by which these antibodies (AChR Ab) disturb the function of the receptor have been elucidated. READ MORE

  7. 5. Genetic control of myasthenia gravis : a study on cytokine and co-stimulator genes and their related functions

    Author : DeRen Huang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Myasthenia gravis (MG) is a classical autoimmune disease characterised by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AchR) on the postsynaptic membrane of the neuromuscular junction. The aim of the study was to identify the role of the genes encoding potential immune components, such as TNF, IL-1, IL-1 receptor antagonist, IL-4, IL-10, and cytotoxic T lymphocyte antigen 4 (CTLA-4) in the pathogenesis of MG. READ MORE