Search for dissertations about: "time-of-flight secondary ion mass spectrometry"

Showing result 16 - 20 of 37 swedish dissertations containing the words time-of-flight secondary ion mass spectrometry.

  2. 16. PROBING SECRETORY VESICLES AND LIPOSOME MODEL SYSTEMS USING NANOSCALE ELECTROCHEMISTRY AND MASS SPECTROMETRY

    Author : Jelena Lovric; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; neuroendocrine cells; NanoSIMS; liposomes; neurotransmitters; large dense core vesicles; Exocytosis; ToF-SIMS; vesicle electrochemical cytometry; electrochemistry; amperometry;

    Abstract : Cellular communication is based on the process of exocytosis, regulated release of chemical messengers into the extracellular space. These messengers, neurotransmitters, are packed into vesicles that during exocytosis fuse with the plasma membrane and release their content. READ MORE

  4. 17. Application of imaging TOF-SIMS in cell and tissue research

    Author : Katrin Richter; Göteborgs universitet; []
    Keywords : TOF-SIMS; imaging mass spectrometry; cryopreparation; ions; lipids; galactosylceramide; sulfatide; fatty acids;

    Abstract : This thesis is aimed at extending the use of TOF-SIMS (time of flight secondary ion mass spectrometry) as an analytical tool in cell and tissue research. TOF-SIMS is a relatively new method that allows analysis of the chemical composition of sample surfaces. READ MORE

  5. 18. Epidemiology, diagnostics and treatment of non-melanoma skin cancers

    Author : Oscar Zaar; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain; non-melanoma skin cancer; basal cell carcinoma; merkel cell carcinoma; Bowen’s disease; imaging mass spectrometry; lipidomics; photodynamic therapy;

    Abstract : Skin cancer, including malignant melanoma and non-melanoma skin cancer (NMSC), is a growing problem due to the increasing incidence in Sweden and in other Caucasian populations. NMSCs are diagnosed as often as all other cancers combined and include basal cell carcinoma (BCC), squamous cell carcinoma (SCC), precursors to SCC such as Bowen’s disease (BD) and actinic keratosis (AK), as well as several rare skin cancers including Merkel cell carcinoma (MCC). READ MORE

  6. 19. Interrogation of drug effects on the lipid composition of single cells and Drosophila brain using ToF-SIMS imaging

    Author : Thuy Mai Hoang Philipsen; Chalmers tekniska högskola; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; Keywords: Mass spectrometry imaging; PC12 cell.; ToF-SIMS; zinc deficiency; lipid change; methylphenidate; cocaine; cognition; omega-3 and 6- fatty acids;

    Abstract : Lipids are essential for all living organisms on Earth. The most important function of lipids is that they act as the building blocks of cellular membranes. Lipids consist of polar head groups and non-polar tail groups and assemble into bilayer structures to create cell and organelle membranes. READ MORE

  7. 20. Combining mass spectrometric tissue imaging with conventional histology : focus on Alzheimer’s disease

    Author : Santiago Solé Domènech; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Historically, most scientific discoveries have been accompanied by previous technological innovation. Representative examples are the introduction of gene sequencing technologies, which allowed for the mapping of the human genome, or the constant improvement in the microscopy field that lead to the introduction of modern multiphoton imaging techniques, allowing for live imaging of body organs in animal specimens. READ MORE