Search for dissertations about: "time-of-flight secondary ion mass spectrometry"

Showing result 6 - 10 of 37 swedish dissertations containing the words time-of-flight secondary ion mass spectrometry.

2. 6. Analysis of phospholipids in cellular membranes with LC and imaging mass spectrometry

   Author : Ingela Lanekoff; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; TOF-SIMS; Phospholipid; Cells; Anammox;

   Abstract : Imaging mass spectrometry enables the creation of molecule specific images from the surface of a solid sample in vacuum. To solve the issue of bringing single cells into vacuum without altering their native distribution of molecules, a freeze fracture device that fits the time of flight secondary ion mass spectrometry (TOF-SIMS) IV instrument has been developed. READ MORE

4. 7. Imaging mass spectrometry for in situ lipidomics: from cell structures to cardiac tissue

   Author : Sanna Sämfors; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Myocardial infarction; PC12 cells; Cell membrane; Mass spectrometry imaging; Sample preparation; Lipidomics; ToF-SIMS; Gas cluster ion beam;

   Abstract : Imaging of cells and tissues is important for studying different processes within biological systems due to the spatial information provided for different molecular species during imaging. One powerful imaging technique is mass spectrometry imaging (MSI). READ MORE

5. 8. Detection of Lipids and Proteins on Biological Surfaces using Imaging Mass Spectrometry

   Author : Louise M Carlred; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ToF-SIMS; GM1; cholesterol; Amyloid-β; phospholipids; Imaging Mass Spectrometry; Alzheimer’s disease; sulfatides; QCM-D; MALDI;

   Abstract : Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a technique that can be used for imaging the spatial distribution of many different molecules at the same time. It is very sensitive for detection of small biomolecules, such as lipids, whereas larger biomolecules, such as peptides and proteins, cannot be detected as intact entities due to fragmentation. READ MORE

6. 9. Single fluid inclusion analysis using ToF-SIMS : Implications for ancient Earth biodiversiy and paleoenvironment studies

   Author : Sandra Siljeström; Jukka Lausmaa; Andrew Steele; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; ToF-SIMS; time-of-flight secondary ion mass spectrometry; fluid inclusions; biomarkers; hopanes; steranes; early life; paleoenvironment; oil; eukaryotes; Earth sciences; Geovetenskap; geokemi; Geochemistry;

   Abstract : When and how life first emerged on the Earth is an area of intense research. Signs of the first life on Earth, including morphological fossils, are scarce and hard to interpret. An alternative approach is to study organic biomarkers, which are molecular fossils commonly considered as bona fide biosignatures. READ MORE

7. 10. Towards Anti-Virulence Antimicrobials, Discovery and Development of Sortase A Inhibitors and Investigations of Bacterial Phenotypes

   Author : Patrick M. Wehrli; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Sortase A; SrtA; Inhibitors; Anti-virulence; Bacterial analysis; FTIR spectroscopy; Bacterial phenotyping; Design of Experiment; Multivariate Data Analysis; PCA; ToF-SIMS; Time-of-flight secondary-ion-mass-spectrometry; Lipid analysis; ppGpp; Stringent response;

   Abstract : Antibiotic resistance is an emerging and serious threat to public health. Immediate actions are required to preserve current antibiotics while intensifying research efforts towards the development of new effective therapeutics. READ MORE