Search for dissertations about: "total synthesis of"

Showing result 1 - 5 of 283 swedish dissertations containing the words total synthesis of.

2. 1. Stereoselective Synthesis of Amino Alcohols : Applications to Natural Product Synthesis

   Author : Staffan Torssell; Peter Somfai; Pher G Andersson; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Amino alcohol; asymmetric 1.3-dipolar cycloaddition; azomethine ylide; carbenoid; carbonyl ylide; cross-metathesis; omuralide; oxazolidine; rhodium; sphingosine; stemoamide; stereoselective synthesis; total synthesis.; Organic chemistry; Organisk kemi;

   Abstract : This thesis is divided into four separate parts with amino alcohols as the common feature. The first part of the thesis describes the development of an efficient three-component approach to the synthesis of α-hydroxy-β-amino esters. READ MORE

4. 2. Enantio- and Regioselective Iridium-Catalyzed Hydrogenation of Olefins : From Development to Total Synthesis

   Author : Cristiana Margarita; Pher Andersson; Xavier Verdaguer; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Asymmetric hydrogenation; Iridium; Regioselectivity; Kinetic resolution; Total synthesis; organisk kemi; Organic Chemistry;

   Abstract : The work presented in this thesis concerns the iridium-catalyzed asymmetric hydrogenation of cyclic olefins and allylic alcohols for the preparation of useful chiral intermediates with various substitution patterns. The strategy provides stereocontrol for both non-functionalized as well as functionalized substrates and aims to be implemented in the stereoselective preparation of chiral building blocks having more than one stereocenter. READ MORE

5. 3. Synthesis of Polyhydroxylated Surfactants : Comparison of Surfactant Stereoisomers and Investigation of Haemolytic Activity

   Author : Kristina Neimert-Andersson; Peter Somfai; Krister Holmberg; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Polyhydroxy surfactants; Sugar surfactants; Dihydroxylation; Metathesis; Langmuir monolayers; Chiral discrimination; Haemolysis; Organic chemistry; Organisk kemi;

   Abstract : I den här avhandlingen har vi studerat hur man kan göra nya tensider. En tensid är en speciell molekyl som har förmågan att lösa sig i både vatten och olja. Man kan göra följande experiment hemma: Fyll en glasburk till hälften med vatten och tillsätt en droppe matolja. READ MORE

6. 4. Synthesis of Indole Alkaloids and Development of New Methodology

   Author : Anita Hoang; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; total synthesis; indole alkaloids; Domino reactions; vicinal quaternary stereocenters; quaternary stereocenter; indoline synthesis; communesin alkaloid; perophoramidine; dehaloperophoramidine; akuammiline alkaloids; strictamine; intramolecular Heck reaction; domino carbopalladation carbonylation; indoline alkaloids;

   Abstract : This thesis describes our efforts towards the total synthesis of natural products and the development of a newmethodology to afford a synthetically important scaffold.Chapter 2 outlines our efforts towards the total synthesis of a marine natural product, perophoramidine as wellas our completed synthesis of dehaloperophoramidine. READ MORE

7. 5. Asymmetric Synthesis of C-Glycosylated Amino Acids : Incorporation in Collagen Glycopeptides and Evaluation in a Model for Rheumatoid Arthritis

   Author : Tomas Gustafsson; Jan Kihlberg; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Total synthesis; stereoselective synthesis; chiral glycine templates; Evan’s alkylation; asymmetric hydrogenation; alpha-amino acid synthesis; C-glycoside; rheumatoid arthritis; MHC; T cell; Organic chemistry; Organisk kemi;

   Abstract : This thesis describes stereoselective syntheses of four amino acids, three of which are C-glycosidic analogues of glycosylated amino acids. The overall goal of the project was to probe the interactions between MHC molecules, glycopeptide antigens and T cell receptors, that are essential for development of collagen induced arthritis. READ MORE