Search for dissertations about: "toxicity assay"

Showing result 1 - 5 of 71 swedish dissertations containing the words toxicity assay.

2. 1. Comparative avian developmental toxicity of PFAAs

   Author : Marcus Nordén; Magnus Engwall; Krister Halldin; Anders Bignert; Örebro universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chicken; herring gull; cormorant; PFAA; PFOS; PFOA; toxicity; levels; Biology; Biologi;

   Abstract : Perfluoroalkyl acids (PFAAs) are persistent organic pollutants that can commonly be found in environmental matrixes and wildlife from all over the globe. The PFAAs have been used in applications such as water and dirt repelling treatments for textiles, oil-resistant paper coatings and fire-fighting foams. READ MORE

4. 2. Pathogenic effects of alpha-synuclein: modifications and toxicity

   Author : Natalie Landeck; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Keywords : Parkinson s disease; adeno-associated viral vector; animal models; alpha-synuclein; substantia nigra; dopaminergic neurons; phosphorylation; aggregation; toxicity;

   Abstract : Accumulation of intraneuronal inclusions, containing mainly a protein called alpha-synuclein (asyn), is thought to play a critical role in neurodegenerative disorders such as Parkinson's disease (PD). In these so called Lewy bodies, the majority of asyn is phosphorylated at serine 129 (pS129) suggesting that post-translational modifications may play a critical role in the process of aggregate formation. READ MORE

5. 3. Melanosome transfer, photoreception and toxicity assays in melanophores

   Author : Daniel Hedberg; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; colour change; melanophores; melanosome; intracellular transport; pigment transfer; photoreception; toxicity assay; Roundup; glyphosate;

   Abstract : Many animals such as fish and frogs have developed the ability to change colour of their skin to adapt to the environment or to signal to other individuals. This ability is due to specialised skin cells called melanophores. READ MORE

6. 4. Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications

   Author : Caroline Haglund; Elin Lindhagen; Rolf Larsson; Anna Åleskog; Sigurd Vitols; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anticancer drugs; In vitro assays; Toxicity testing; Haematological toxicity; Primary tumour cells; Species difference; Clinical pharmacology; Klinisk farmakologi; Clinical Pharmacology; Klinisk farmakologi;

   Abstract : Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. READ MORE

7. 5. Evaluation of process parameters and treatments of different raw materials for biogas production

   Author : Malik Badshah; Bioteknik; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Anaerobic digestion; biogas; lignocellulosics; inoculum to substrate ratio; feed composition; toxicity; furaldehydes; paper and pulp sludges.;

   Abstract : The anaerobic digestion process results in the production of biogas from a large diversity of organic residues, which can be used as an alternate source of energy generation and for waste management. However, the biogas production technology is not exploited efficiently due to the characteristics of raw materials, poor methane yields, process instability, limited raw materials and lack of knowledge about the process. READ MORE