Search for dissertations about: "transforming growth factor beta"

Showing result 1 - 5 of 54 swedish dissertations containing the words transforming growth factor beta.

2. 1. Insulin-like Growth Factor System: functional role and regulation in carcinomas

   Author : Ann Rosendahl; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Cytology; PTEN; Transforming Growth Factor-beta; Insulin-like Growth Factor; Renal Cell Carcinoma; Cytologi; onkologi; cancer; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Abstract : The insulin-like growth factor (IGF) system demonstrates numerous actions during neoplastic growth and is therefore an interesting target with potential clinical implications. While numerous studies have established important roles of the IGF system in regulating cellular growth and survival of several tumor forms, very limited reports exist regarding its role in renal cell carcinoma (RCC). READ MORE

4. 2. Growth factor regulation of the urokinase plasminogen activator (uPA) system in human endometrium, and the significance of uPA receptor activation in endometrial angiogenesis

   Author : Tove Sandberg; Lund Obstetrik och gynekologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics; endothelial cell migration; angiogenesis; uPA:PAI-1 complex; uPAR; TGF-beta; PAI-1; EGF; uPA; Growth factor; gynaecology; andrology; reproduction; sexuality; Obstetrik; gynekologi; andrologi; reproduktion; sexualitet;

   Abstract : The purpose of this thesis was to examine the role of growth factors and the urokinase plasminogen activator (uPA) system in human endometrial angiogenesis. Growth factors as well as progesterone increased expression of the main inhibitor of uPA (PAI-1) in primary cultures of endometrial stromal cells. READ MORE

5. 3. Transcriptional Regulation of the Platelet-Derived Growth Factor beta-receptor

   Author : Anders Hackzell; Göteborgs universitet; []
   Keywords : PDGF; cell cycle; p73; p53; SV40; NF-Y; Sp1; Myc;

   Abstract : The Platelet Derived-Growth Factor (PDGF) receptors and ligands are expressed in cells of predominantly mesenchymal origin. Binding of the ligands to the receptors stimulates cell proliferation and other cellular responses such as differentiation and cell movement. READ MORE

6. 4. Molecular studies of pancreatic cancer: Characterization of the transforming growth factor beta signaling pathway

   Author : Tord Jonson; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SMAD4; PCR; FISH; cytogenetics; chromosome; pancreatic cancer; TGFB signaling; cytogenetik; Genetik; Genetics;

   Abstract : In the present thesis, genetic abnormalities in pancreatic cancer were studied, with special emphasis on alterations of components involved in the transforming growth factor beta (TGFB) signaling pathway. In the first study, fluorescence in situ hybridization and cytogenetic analyses revealed aberrations of chromosome 18 in all 13 pancreatic carcinoma cell lines studied, in particular frequent breaks close to the centromere of chromosome arm 18q. READ MORE

7. 5. Growth factors in spermatogenesis

   Author : Aida Wahlgren; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Testis; seminiferous tubules; proliferation; growth factors; sex steroids;

   Abstract : The aim of this study was to increase the knowledge of die effects of locally produced growth factors and hormones on germ cell proliferation in rat testis in vitro. Since impaired sperm production and function accounts for half the cases of infertility, it is important to understand the physiological actions in germ cell development. READ MORE