Search for dissertations about: "transmitter release"

Showing result 1 - 5 of 30 swedish dissertations containing the words transmitter release.

2. 1. Communication breakdown - synaptic dysfunction in Huntington's disease

   Author : Ruben Smith; Neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurodegeneration; Neurology; neuropsychology; neurophysiology; Neurologi; cholinergic neuron; exocytosis; transmitter release; intracellular transport; insulin; Huntington s disease; synapse; neuropsykologi; neurofysiologi;

   Abstract : Huntington's disease (HD) is a neurodegenerative disease caused by a CAG-triplet expansion in the gene encoding the protein huntingtin. The disease typically starts in mid-life and progresses for 15-20 years. To date no effective treatment is available for curing the disease. HD primarily affects the striatum, cerebral cortex and hypothalamus. READ MORE

4. 2. Mechanisms underlying sustained synaptic release of glutamate

   Author : Oleg Shupliakov; Karolinska Institutet; Karolinska Institutet; []
   Keywords : synaptic transmission; synaptic vesicle proteins; synapsin; glutamate; glutamine; glutamate uptake; glia; spinal cord; hippocampus; neuromuscular junction; lamprey; crayfish; mouse.;

   Abstract : Fast communication between neurons in the brain is mediated mainly by amino acid transmitters, such as glutamate, GABA and glycine. These transmitters are stored in small synaptic vesicles which undergo exocytosis at synaptic release sites (active zones) in response to action potentials. READ MORE

5. 3. Neuronal release and function of nitric oxide in smooth muscle

   Author : Henrik H Iversen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Autonomic neurotransmission; gastrointestinal tract; nitric oxide; nitric oxidesynthase; smooth muscle; urinary tract.;

   Abstract : The aim of the present thesis was to study nitric oxide (NO) as an effector molecule in autonomic neurotransmission. The nitrergic transmitter was examined with regard to its pharmacological profile, stimuli of release, release pattern, and effects in gastrointestinal and urinary tract smooth muscle. READ MORE

6. 4. Cyanide and central nervous system : a study with focus on brain dopamine

   Author : Gudrun Cassel; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CNS; cyanide; dopaminergic system; convulsions; receptor binding; tyrosine hydroxylase; monoamine oxidase; extracellular release; inositol phosphate; GABA; GAD;

   Abstract : The brain is a major target site in acute cyanide intoxication, as indicated by several symptoms and signs. Cyanide inhibits the enzyme cytochrome oxidase. This inhibition causes impaired oxygen utilization in all cells affected, severe metabolic acidosis and inhibited production of energy. READ MORE

7. 5. Regulation by glutamate- and adenosine-receptors of dopamine and acetylcholine release from rat striatal slices

   Author : Shaoyu Jin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : striatum; dopamine; acetylcholine; adenosine receptors; glutamatereceptors. ISBN 91-628-2599-2;

   Abstract : The striatum, which is critically involved in sensory motor integration, receives an excitatory glutamatergic input from the cerebral cortex and the thalamus. The effects of the glutamatergic stimulation are modulated by dopamine (DA) released from a prominent dopaminergic input, acetylcholine (ACh) released from cholinergic interneurons and by the ubiquitous neuromodulator adenosine. READ MORE