Search for dissertations about: "trial design"

Showing result 1 - 5 of 318 swedish dissertations containing the words trial design.

  2. 1. Understanding Energy Behaviour – A Necessity for Supporting Domestic Energy Conservation through Design

    Author : Anneli Selvefors; Chalmers tekniska högskola; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; HUMANIORA; HUMANITIES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Energy conservation; energy behaviour; domestic energy consumption; design for sustainable behaviour; energy feedback;

    Abstract : Domestic energy consumption is continuing to increase and the need to decrease consumption is growing more evident. In this research, two studies were conducted to further the understanding of domestic energy behaviour and increase the knowledge of how energy conservation can be supported. READ MORE

  4. 2. Online support for informal carers of persons with heart failure : Focus on perceptions, development and experiences

    Author : Hanna Allemann; Ingela Thylén; Anna Strömberg; Maria Giovinazzo Brovall; Linköpings universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Informal carers; Heart failure; Online support; Co-design; Cross-sectional design; Qualitative design; Descriptive design; Anhöriga; Hjärtsvikt; Online-stöd; Co-design; Tvärsnittsdesign; Kvalitativ design; Deskriptiv design.;

    Abstract : Background: Heart failure (HF) is a common condition, and its prevalence is expected to increase. The illness trajectory is unpredictable, and its effects will include a potential impact on informal carers, i.e., family, friends, and significant others. READ MORE

  5. 3. Optimal (Adaptive) Design and Estimation Performance in Pharmacometric Modelling

    Author : Alan Maloney; Ulrika Simonsson; Mats Karlsson; Andy Grieve; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phase II; dose response; optimal design; adaptive design; exposure response; count data;

    Abstract : The pharmaceutical industry now recognises the importance of the newly defined discipline of pharmacometrics. Pharmacometrics uses mathematical models to describe and then predict the performance of new drugs in clinical development. READ MORE

  6. 4. Model-Based Optimization of Clinical Trial Designs

    Author : Camille Vong; Mats O. Karlsson; Andrew C. Hooker; Lena E. Friberg; Marylore Chenel; Oliver Sander; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. READ MORE

  7. 5. A computer-aided approach to design of robust analog circuits

    Author : Emil Hjalmarson; Georges G.E. Gielen; Linköpings universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Analog circuit design; computer-aided design; Electrical engineering; Elektroteknik;

    Abstract : Traditional design methods for analog circuits are based on rules-of-thumbs, experience, and trial-and-error approaches involving the use of circuit simulators. It is an unstructured process, which is time-consuming, error prone, and requires the attention of a skilled analog designer. READ MORE