Search for dissertations about: "trisomy 12"

Showing result 1 - 5 of 12 swedish dissertations containing the words trisomy 12.

2. 1. Cytogenetic studies of primary and metastatic breast cancer

   Author : Adewale Adeyinka; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; histokemi; cytokemi; Histologi; tissue culture; cytochemistry; histochemistry; Histology; metastases; prognosis; male breast cancer; breast cancer; trisomy 12; Cytogenetics; chromosomes; vävnadskultur; Clinical genetics; Klinisk genetik;

   Abstract : A series of primary and metastatic breast carcinomas obtained from female and male patients were cytogenetically analysed. Trisomy 12 was identified as a recurrent and sometimes early event in breast carcinogenesis. READ MORE

4. 2. Chronic leukemic B-cell disorders and trisomy 12 : a study of surface markers, protein expression and clinical course

   Author : Viktoria Hjalmar; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Chronic lymphocytic leukemia of B-cell type (CLL) is the most common disease entity of chronic leukemic B-cell disorders (CLBD). CLL is the most frequent leukemia in the Western world and the incidence is increasing. The clinical course is very variable and specific therapy is not always needed. READ MORE

5. 3. Cytogenetic studies of normal kidney tissue and renal cell carcinoma

   Author : Peter Elfving; Malmö (Abrahamsson) Urologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; Klinisk genetik; Clinical genetics; nonneoplastic kidney tissue; renal cell carcinoma; trisomy 7; Cytogenetics; FISH; oncology; cancerology; Cytologi; onkologi; cancer;

   Abstract : In the present thesis normal kidney tissue and renal cell carcinoma (RCC) were studied by cytogenetic and fluorescence in situ hybridization (FISH) methods to investigate chromosomal aberrations. In the first study, 4 samples of nonneoplastic kidney tissue were cultured for cytogenetic analysis and trisomy 7 was found in all cases in 3-15% of the cells. READ MORE

6. 4. Characterization of somatic mutations in nonneoplastic cells

   Author : Karin Broberg; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; osteoarthritis; nonneoplastic; HMGIC; trisomy 7; FISH; Molecular genetics; cytogenetics; Klinisk genetik;

   Abstract : Acquired genetic alterations, of which many are visible on the chromosome level, are believed to be necessary for tumorigenesis, and most tumors display characteristic patterns of recurrent structural and numerical aberrations. However, two of the most frequently occurring chromosome mutations in malignant and benign solid tumors, i.e. READ MORE

7. 5. Chromosome aberrations and environmental exposures in acute leukemia

   Author : Ragnhild Rosengren Lindquist; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Acute leukemia; chromosome 3; chromosome 8; fragile site; occupational exposure; mutagen exposure; case-control study; trisomy; benzene; organic solvent; petroleum; epidemiology; environmental carcinogens; painter; driver;

   Abstract : The aims of this thesis are to evaluate the role of environmental exposures, especially professional exposure to organic solvents and petroleum products in the etiology of acute leukemia and to investigate if there is a correlation between the exposure to a specific leukemogen factor and a clonal chromosome aberration of the leukemic cells. Papers I and II present results of a case-control study of environmental exposures, in all occupations during life-time, medical treatments with medicines, chemotherapy and radiation, tobacco-use and the exposure to chemical compounds in private life in 120 patients with acute leukemia and of 120 controls, matched for age (+ 4 years), residence and sex. READ MORE