Search for dissertations about: "trypanosoma thesis, gene expression"

Showing result 1 - 5 of 8 swedish dissertations containing the words trypanosoma thesis, gene expression.

  2. 1. A Genetic Survey of the Pathogenic Parasite Trypanosoma cruzi

    Author : Anh-Nhi Tran; Lena Åslund; John Kelly; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Trypanosoma cruzi; Chagas ; gene discovery; EST; sequencing; DGC3; repeats; gene family; CL Brener; trypanothione synthetase; TcTRS locus; alleles; polymorphism; RNA-binding protein; TcPTB; stage-specific expression; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

    Abstract : Trypanosoma cruzi, the causative agent of Chagas´ disease, is an evolutionarily ancient species with distinct biological and immunological characteristics. A fundamental understanding of the basic biology of the parasite is necessary in order to develop reliable therapeutic and prophylactic agents against T. cruzi. We have, as a part of the T. READ MORE

  4. 2. Gene Regulation and Epigenetic Mechanisms in the Parasite Trypanosoma cruzi

    Author : Patricia Respuela; Lena Åslund; George A.M. Cross; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular Biology; Molekylärbiologi;

    Abstract : Trypanosomes are unicellular protozoan parasites responsible for several human diseases that affect millions of people and cause thousands of casualties every year. They also represent a primitive eukaryotic model system harboring unique processes and basic regulatory mechanisms such as RNA-editing, polycistronic transcription and trans-splicing, first described in these organisms. READ MORE

  5. 3. Genome and transcriptome studies of the protozoan parasites Trypanosoma cruzi and Giardia intestinalis

    Author : Oscar Franzén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Trypanosoma cruzi and Giardia intestinalis are two human pathogens and protozoan parasites responsible for the diseases Chagas disease and giardiasis, respectively. Both diseases cause su ering and illness in several million individuals. READ MORE

  6. 4. Genomic feature identification in trypanosomatid parasites

    Author : Daniel Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Trypanosoma cruzi; genome sequence; bioinformatics; gene finding; Trypanosoma brucei; Leishmania major; strand asymmetry; trans splicing; polyadenylation; post-transcriptional control; uAUGs.;

    Abstract : The trypanosomatid parasites cause death and suffering, among humans as well as livestock. Current drugs lack efficacy and cause severe side effects, and no vaccines are available. Increased knowledge of the biology of the parasites is vital for the development of new drugs. READ MORE

  7. 5. Immunological studies in the brain and signaling pathways in experimental African trypanosomiasis

    Author : Ahmed Sharafeldin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Trypanosoma brucei; Cytokines; Chemokines; IFN-gamma; Transcription factors;

    Abstract : African Trypanosomiasis is a disease prevalent among humans and animals in tropical Africa which is caused by the extracellular hemoflagellate Trypanosoma brucei (T. b.). READ MORE