Search for dissertations about: "ubiquitin proteasome"

Showing result 1 - 5 of 73 swedish dissertations containing the words ubiquitin proteasome.

  2. 1. The p97 ATPase and the Drosophila Proteasome : Protein Unfolding and Regulation

    Author : Kristian Björk Grimberg; Patrick Young; Neus Visa; Lars Thelander; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; proteasome; ubiquitin; p97; unfolding; regulation; RNAi screen; high-throughput screen; cnc; basic leucine zipper; transcription factors; proteasome inhibition; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : For all living systems, there is a requirement to recycle and regulate proteins. In eukaryotic organisms this is accomplished by the proteasome. The p97 ATPase is another highly conserved and essential complex present throughout the eukaryotic cell. READ MORE

  4. 2. The Path to Destruction : Understanding the mechanism and regulation of proteasomal degradation

    Author : Anne Beskow; Patrick Young; Ylva Engström; Bernat Crosas; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Proteasome; ubiquitin; p97; Cnc-C; transcription factors; Nrf1; Nrf2; Molecular Biology; molekylärbiologi;

    Abstract : A majority of intracellular proteins are degraded by the ubiquitin proteasome system (UPS). In this thesis, both the mechanism of the degradation and the regulation of UPS have been investigated. The importance of the p97 ATPase for proteasomal degradation of cytosolic substrates was examined. READ MORE

  5. 3. Protein Quality Control at the Inner Nuclear Membrane – The Asi complex in Saccharomyces cerevisiae

    Author : Marina Pantazopoulou; Per Ljungdahl; Jaspersen Sue; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; nuclear envelope; nuclear quality control NQC ; ubiquitin; proteasome; inner nuclear membrane-associated degradation INMAD ; Cell Biology; cellbiologi;

    Abstract : The nuclear envelope is a barrier comprised of outer and inner membranes that separate the cytoplasm from the nucleoplasm. The outer (ONM) and inner (INM) membranes have different physical characteristics and protein compositions. READ MORE

  6. 4. The ubiquitin-proteasome system during proteotoxic stress

    Author : Victoria Menéndez Benito; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ubiquitin; proteasome; green fluorescent protein GFP ; degradation; inhibitor; neurodegeneration; stress;

    Abstract : The dual function of the ubiquitin-proteasome system in protein quality control and as a master regulator of vital cellular processes places the system in a delicate position. This might be particularly relevant under patho-physiological conditions such as endoplasmic reticulum stress, which provoke the accumulation of aberrant proteins. READ MORE

  7. 5. Studies of metazoan proteasome function and regulation

    Author : Josefin Lundgren; Patrick Young; Michael Glickman; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; proteasome ubiquitin RNAi microarray; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Biological processes depend upon the structural and functional quality of the molecules that comprise living organisms. The integrity of molecules such as DNA, RNA, proteins, carbohydrates and lipids is crucial and the precise three-dimensional shape and the detailed chemistry of these molecules orchestrate the biochemical processes vital for life. READ MORE