Search for dissertations about: "umeå, amyloid"

Showing result 1 - 5 of 38 swedish dissertations containing the words umeå, amyloid.

2. 1. The amyloid : structure, properties and application

   Author : Mantas Malisauskas; Ludmilla Morozova-Roche; Fabrizio Chiti; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; oligomers; AFM; cytotoxicity; biotemplating; lysozyme; Biochemistry; Biokemi;

   Abstract : Protein aggregation, leading to the formation and depositions of amyloids, is a cause for a number of diseases such as Alzheimer’s and Creutzfeld-Jacob’s disease, systemic amyloidoses, type II diabetes and others . More than 20 proteins are associated with protein misfolding diseases and even a larger number of proteins can self-assemble into amyloid in vitro. READ MORE

4. 2. Synthesis of Ring-fused Peptidomimetics : Interacting with Amyloid Fibrils

   Author : Dan E. Adolfsson; Fredrik Almqvist; Anna Linusson; Morten Grötli; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; synthesis; peptidomimetics; thiazoline fused 2-pyridones; Alzheimer s disease; Parkinson s disease; Amyloid; Amyloid-beta; alfa-Synuclein; method development; organisk kemi; Organic Chemistry;

   Abstract : Parkinson's and Alzheimer's disease are the two most common neurological disorders in humans. Both conditions involve progressive death of neurons in the central nervous system, decline in bodily functions and eventually (and invariably), death. So far, no cure exists and the available treatments can only ease symptoms. READ MORE

5. 3. Targeting cytotoxic species in amyloid diseases

   Author : Malin Lindhagen Persson; Anders Olofsson; Lars Tjernberg; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Amyloid-beta; transthyretin; FAP; amyloid; cytotoxic species; oligomers; medicinsk biokemi; Medical Biochemistry;

   Abstract : Amyloid diseases are a world-wide problem causing great human suffer and large economical costs. Although amyloid deposits, a common denominator in all amyloid disorders, are detrimental to the surrounding tissue, there is a poor correlation between total amyloid burden and clinical symptoms. READ MORE

6. 4. Mechanisms involved in amyloid induced cytotoxicity

   Author : Johan Östman; Lars Lannfelt; Umeå universitet; []
   Keywords : amyloid; transthyretin; cytotoxicity; apoptosis; caspases; aggregation; molekylärbiologi; Molecular Biology;

   Abstract : Amyloidoses comprise a group of diseases where normal or mutated protein precipitates into amyloid fibrils. The deposition of fibrils causes dysfunction of organs and toxicity to nervous tissue. Up to date, 24 different proteins and peptides are known to be able to form amyloid fibrils. READ MORE

7. 5. Kinetic stabilization of transthyretin and its role as an inhibitor of Aβ amyloid formation

   Author : Lina Nilsson; Anders Olofsson; Elisabeth Sauer-Eriksson; Gunilla Westermark; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Amyloid; transthyretin; amyloid beta; kinetic stabilizer; biokemi; Biochemistry;

   Abstract : Amyloid formation occurs when normally soluble proteins and peptides misfold and aggregate into intractable threadlike structures called fibrils. There are currently more than 30 proteins associated with this aberrant structure, including the Aβ peptide in Alzheimer’s disease (AD) and transthyretin (TTR) in TTR amyloidosis. READ MORE