Search for dissertations about: "variant calling"
Showing result 1 - 5 of 7 swedish dissertations containing the words variant calling.
-
1. Analysis of RNA and DNA sequencing data : Improved bioinformatics applications
Abstract : Massively parallel sequencing has rapidly revolutionized DNA and RNA research. Sample preparations are steadfastly advancing, sequencing costs have plummeted and throughput is ever growing. This progress has resulted in exponential growth in data generation with a corresponding demand for bioinformatic solutions. READ MORE
-
2. The roles of demography and natural selection in shaping genome-wide variation of Norway spruce
Abstract : Understanding the relative contribution of genetic drift, natural selection, and mutation to genetic variation, and quantifying adaptive evolution and the effects of natural selection in species are enduring goals of evolutionary genetics. Norway spruce (Picea abies) is one of the most important conifer species that dominates from both an ecological and economical point of view in many boreal ecosystems. READ MORE
-
3. Next generation molecular diagnostics using ultrasensitive sequencing
Abstract : Massively parallel sequencing enables the exploration of the genetic heterogeneity within microbial, viral and tumor cell populations. Detecting circulating tumor DNA in blood and other body fluids has the potential to revolutionize molecular diagnostics. READ MORE
-
4. Methods for deep examination of DNA
Abstract : The development of sequencing technology has had a rapid pace during the last years and today, the sequencing instruments harbors enormous capacity. This thesis is about the development of methods to make the most out of this capacity and to use it for various applications. READ MORE
-
5. Human demographic history : Insights on the human past based on genomes from Southern through Central Africa
Abstract : Evidence from paleontology, archaeology and population genetics support that modern humans originated in Africa. While the out-of-Africa event and subsequent colonization of all continents are well documented, human history in Africa at that time and before is less studied. READ MORE