Search for dissertations about: "vascular engraftment"

Showing result 1 - 5 of 15 swedish dissertations containing the words vascular engraftment.

2. 1. Implantation-Site Dependent Differences in Engraftment and Function of Transplanted Pancreatic Islets

   Author : Joey Lau; Per-Ola Carlsson; Leif Jansson; Carina Carlsson; Caroline Kampf; Annika Tibell; Uppsala universitet; []
   Keywords : Cell biology; Type 1 diabetes; pancreatic islets; human islets; islet transplantation; vascular engraftment; revascularization; implantation-site; microenvironment; vascular density; insulin release; pro insulin biosynthesis; glucose oxidation; Cellbiologi;

   Abstract : Transplanting pancreatic islets into the liver through the portal vein is currently the most common procedure in clinical islet transplantations for treating patients with brittle type 1 diabetes. However, most islet grafts fail within a 5-year period necessitating retransplantation. READ MORE

4. 2. Properties of Endothelium and its Importance in Endogenous and Transplanted Islets of Langerhans

   Author : Åsa Johansson; Per-Ola Carlsson; JanOve Sehlin; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; islet transplantation; endothelial cells; engraftment; beta cells; Diabetology; Diabetologi; Medical Cell Biology; medicinsk cellbiologi;

   Abstract : Transplantation of insulin producing cells is currently the only cure for type 1 diabetes. However, even though the Edmonton protocol markedly increased the success rate of pancreatic islet transplantation, the long term insulin independence is still very poor. An adequate engraftment is critical for islet graft survival and function. READ MORE

5. 3. The Microvasculature of Endogenous and Transplanted Pancreatic Islets : Blood Perfusion, Oxygenation and Islet Endocrine Function

   Author : Richard Olsson; Per-Ola Carlsson; Leif Jansson; Arne Andersson; Thomas Linn; Uppsala universitet; []
   Keywords : Cell biology; diabetes mellitus; pancreatic islets; islet transplantation; vascular engraftment; islet microcirculation; oxygenation; blood flow; protein biosynthesis; Cellbiologi;

   Abstract : Type 1 diabetes mellitus affects millions of people worldwide. Islet transplantation is a minimal invasive surgical procedure that restores euglycemia and halts the progression of diabetic complications. However, despite transplantation of islets from multiple donors most patients reverse to hyperglycemia within five years. READ MORE

6. 4. Modifying xenogeneic immune recognition and engraftment by genetic engineering

   Author : Zhong He; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Xenotransplantation; gene therapy; gene transfer; endothelium; promoters; monocytes; NK cells; alpha-Gal; lentivirus vectors; pancreatic islets;

   Abstract : Transplantation using xenogenic organs, tissues and cells (i.e. xenotransplantation) is a potential solution to the shortage of those from human sources. Vascular endothelial cells (ECs) are the most immediate barrier between the xenogeneic donor organ and the host defense systems. READ MORE

7. 5. Experimental Studies on the Vasculature of Endogenous and Transplanted Islets of Langerhans

   Author : Göran Mattsson; Leif Jansson; Alberto Hayek; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; islets of Langerhans; endothelial cells; islet transplantation; vascular density; diabetes mellitus; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

   Abstract : The blood vessels of the pancreatic islets are of crucial importance for oxygen and metabolite supply as well as dispersal of secreted hormones. In addition to this, endothelial cells have an important role in the revascularization process after islet transplantation. READ MORE