Search for dissertations about: "viral hepatitis"
Showing result 11 - 15 of 90 swedish dissertations containing the words viral hepatitis.
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11. The impact of viral vaccines in immunosuppressed and at-risk individuals
Abstract : Vaccines have saved millions of lives, but for some individuals with a defective immune system the protection may be uncertain. This thesis aims to assess the immune response following viral vaccines in immunocompromised patients and in other groups at-risk. READ MORE
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12. Genetic variability of hepatitis B virus in chronic infection
Abstract : Chronic hepatitis B is a major health problem, and may lead to cirrhosis and hepatocellular carcinoma. The liver damage in hepatitis B virus (HBV) infection is considered to be a result of the immune response, and not a cytopathic effect of the virus itself. READ MORE
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13. The hepatitis B virus – Insights into genetic variability, evolution and Bayesian phylogeographic inference
Abstract : In terms of genome size, the hepatitis B virus is the smallest virus known to infect humans and its compactness with multiple overlapping reading frames puts restraints on the emergence of mutations. In the papers included in this thesis we aimed to investigate genetic variation within the precore and core promoter region and to describe the origin, spread and diversification of HBV genotype A. READ MORE
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14. Opportunistic viral infection after paediatric transplantation
Abstract : Background: Opportunistic viral infections can cause considerable morbidity and mortality in organ and stem cell transplanted (SCT) patients, mainly due to iatrogenic T cell dysfunction. Whereas in SCT patients, in general the immunosuppressive treatment can be discontinued after 6-12 months, for the majority of organ transplanted patients, the need for treatment is life-long. READ MORE
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15. On the outcome of antiviral therapy for hepatitis C virus genotype 2 or 3 infection
Abstract : Abstract Approximately 80% of patients infected with HCV genotypes 2 or 3 achieve a sustained virological response (SVR), following 24 weeks of therapy with ribavirin and pegylated interferon (peg-IFN), but in light of considerable side effects and cost, shortened treatment duration without impaired efficacy is desirable. Thus, 382 genotype 2/3 infected patients were randomized in an investigator-initiated phase III study (NORDynamIC) evaluating the efficacy of 12 (short-term) vs. READ MORE