Search for dissertations about: "vitiligo"

Showing result 1 - 5 of 11 swedish dissertations containing the word vitiligo.

  2. 1. Vitiligo and Piebaldism : Treatmant of Leucoderma by Transplantation of autologous melanocytes

    Author : Mats J. Olsson; Hugh Zachariae; Uppsala universitet; []
    Keywords : Medical sciences; leucoderma; leukoderma; vitiligo; piebaldism; melanocytes; pigmentation; cell culturing; serum-free; transplantation; surgery; autoimmune disease; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Dermatology and Venerology; dermatologi och venereologi;

    Abstract : Background: Vitiligo and piebaldism are disorders in which the affected skin lack epidermal melanocytes. Vitiligo is acquired and can clinically be subgrouped, but the aetiology is still not fully understood. The most common type, generalized vitiligo (vitiligo vulgaris) has autoimmune involvement and affects about 1. READ MORE

  4. 2. Alopecia and vitiligo in autoimmune polyendocrine syndrome type I

    Author : Håkan Hedstrand; Uppsala universitet; []
    Keywords : Medical sciences; APS I; autoantigen; vitiligo; alopecia areata; cDNA-library; immunoscreening; tyrosine hydroxylase; SOX9; SOX10; molecular mimicry; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Autoimmune polyendocrine syndrome type I (APS I) is a recessively inherited disease caused by mutations in a recently identified gene, AIRE, on human chromosome 21. APS I patients are affected by autoimmune destruction of multiple endocrine glands and other organs as well as ectodermal structures. READ MORE

  5. 3. Antibody-based Profiling of Expression Patterns using Cell and Tissue Microarrays

    Author : Sara Strömberg; Fredrik Ponten; Joakim Lundeberg; Anna Asplund; Stephen Hewitt; Uppsala universitet; []
    Keywords : Pathology; antibody-based proteomics; tissue microarray; cell line; immunohistochemistry; melanocytes; image analysis; biomarker; Patologi;

    Abstract : In this thesis, methods to study gene and protein expression in cells and tissues were developed and utilized in combination with protein-specific antibodies, with the overall objective to attain greater understanding of protein function.To analyze protein expression in in vitro cultured cell lines, a cell microarray (CMA) was developed, facilitating antibody-based protein profiling of cell lines using immunohistochemistry (IHC). READ MORE

  6. 4. Resident T cells in human skin : functional heterogeneity and clinical implications

    Author : Stanley Sing Hoi Cheuk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The skin forms a critical barrier against the external environment and is therefore frequently challenged by infections and subjected to immune-mediated diseases as well as malignancies. The Tissue-Resident Memory T (TRM) cell is a subset of T cells that resides at sites of previous infection in the skin and other epithelial tissues. READ MORE

  7. 5. Resident T cells steer tissue responses in human skin

    Author : Borislav Ignatov; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The human skin constitutes a biological barrier against threats to the body from the surrounding environment. Tissue-resident memory cells (TRM) reside in the skin and provide local memory of previous encounters with microbes and pathogens, are poised to promptly eliminating infected cells and elicit tissue-wide defense state. READ MORE