Search for dissertations about: "weight-drop model"

Found 5 swedish dissertations containing the words weight-drop model.

  2. 1. Genomic clues to secondary injury mechanisms in brain trauma

    Author : Christina von Gertten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : traumatic brain injury; cerebral cortical contusion; weight-drop model; depolarisation; gene expression; nestin; MMP-9; TIMP-1; osteopontin; CD44; hippocalcin; NMDA receptor; microarray; rat;

    Abstract : Traumatic brain injury (TBI) is a heterogenous disease that can lead to persistent disability or death. The immediate mechanical disruption of brain tissue is followed by a phase of secondary brain injury. During this phase TBI challenges clinical interventions due to its complexity. READ MORE

  4. 2. Genetics in experimental traumatic brain injury

    Author : Faiez Al Nimer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Traumatic brain injury (TBI) is the leading cause of death and disability in the young population in the industrialized world. It comprises a heterogeneous group of brain pathologies where head trauma initiates a series of complex molecular pathways, which, together with the initial injury, account for the final outcome. READ MORE

  5. 3. Human neural stem cell transplantation in experimental brain trauma

    Author : André Wennersten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Traumatic brain injury (TBI) is the leading cause of death and disability in young adults in the industrialized world. Human neural stem/progenitor cells (hNSCs) can be expanded in culture and have the ability to differentiate into the major cell types of the adult brain. READ MORE

  6. 4. Mechanisms of traumatic brain injury in the rat : Morphological consequences and neurotrophic responses

    Author : Anders Lewén; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Cortical contusion injury; TBI; neurons; axons; dendrites; APP; MAP2; BMPR-II; ActR-I; trkB; c-fos; BDNF; PACAP; TUNEL; TGFs; serine threonine; bone morphogenetic protein; neuropeptides; reactive oxygen species; ROS; apoptosis; Neurovetenskap; Neurology; Neurologi; Neurosurgery; neurokirurgi;

    Abstract : Traumatic brain injury is a major cause of death and disability in the Western world. especially in young people. Understanding the pathophysiology of traumatic brain injury is the basis for further development of better therapeutic strategies for such patients. READ MORE

  7. 5. Directed differentiation of adult neural stem cells for cell therapy in the nervous system

    Author : Niklas Holmström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The emergence of neural stem cell research has raised hopes for cell therapy of neurological disorders. Insight into the normal mechanisms of neural stem cell fate specification and differentiation is a prerequisite for the development of safe and efficient clinical applications. READ MORE