Search for dissertations about: "x-ray discovery"

Showing result 1 - 5 of 44 swedish dissertations containing the words x-ray discovery.

2. 1. Probing unoccupied electronic states in aqueous solutions

   Author : Lars-Åke Näslund; Anders Nilsson; Hendrik Bluhm; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; x-ray absorption; x-ray absorption spectroscopy; XAS; NEXAFS; water; liquid water; aqueous solution; hydrogen bond; hydrogen bond network; local geometry; Physics; Fysik;

   Abstract : Water is one of the most common compounds on earth and is essential for all biological activities. Water has, however, been a mystery for many years due to the large number of unusual chemical and physical properties, e.g. decreased volume during melting and maximum density at 4 °C. READ MORE

4. 2. Fragment-based drug discovery : Novel methods and strategies for identifying and evolving fragment leads

   Author : Edward A. FitzGerald; Helena Danielson; Hanna-Kirsti Schrøder Leiros; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Drug Discovery; Biophysics; Fragment-based drug discovery; Epigenetics; Biosensors; Surface Plasmon Resonance; Interaction Analysis; Second-Harmonics; Biokemi; Biochemistry;

   Abstract : The need for new drugs became ever more apparent in the year 2020 when the world was faced with a viral pandemic. How drugs are discovered and their relevance to society became part of daily discussions in workplaces and homes throughout the world. Consequently, efficient strategies for preclinical drug discovery are clearly needed. READ MORE

5. 3. Novel glycomimetic inhibitors and proteolysis-targeting chimeras for human galectins

   Author : Mujtaba Hassan; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Galectins; Galectin-3; Galectin-8; benzimidazole; affinity; selectivity; X-ray; PROTAC;

   Abstract : Galectins are a family of soluble proteins that bind β-D-galactopyranoside-containing glycoconjugates through their conserved carbohydrate-recognition domains. Galectins have emerged as promising drug targets due to their involvement in various pathological conditions, such as tumor growth and metastasis, autoimmune and inflammatory diseases, as well as metabolic disorders. READ MORE

6. 4. Surface-Induced Modification of Supported Late Transition Metal Complexes

   Author : Olesia Snezhkova; Synkrotronljusfysik; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; N-heterocyclic carbene palladium complexes; X-ray photoelectron spectroscopy; electron charge transfer; iron phthalocyanine; catalysis; X-ray absorption spectroscopy;

   Abstract : The work presented in this thesis addresses the investigation of the electronic, magnetic, and structural properties of late transition metal complexes supported on various surfaces. The research is aimed at studying the interaction between the molecules and the support, together with the intermolecular interaction. This knowledge is essential e.g. READ MORE

7. 5. Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase

   Author : Lotta Berg; Anna Linusson; Fredrik Ekström; Joel L. Sussman; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; drug discovery; density functional theory; hydrogen bond; nerve-agent antidote; non-covalent interaction; protein-ligand complex; structure-based design; thermodynamics; X-ray crystallography; datorlingvistik; computational linguistics;

   Abstract : The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. READ MORE