Design and analysis of response selective samples in observational studies

University dissertation from Stockholm : Department of Mathematics, Stockholm University

Author: Maria Grünewald; Stockholms Universitet.; [2011]

Keywords: NATURVETENSKAP; NATURAL SCIENCES; ascertainment; missing data; outcome dependent sampling; response selective samples; sequential design; stochastic EM algorithm; MATHEMATICS Applied mathematics Mathematical statistics; MATEMATIK Tillämpad matematik Matematisk statistik; matematisk statistik; Mathematical Statistics;

Abstract: Outcome dependent sampling may increase efficiency in observational studies. It is however not always obvious how to sample efficiently, and how to analyze the resulting data without introducing bias. This thesis describes a general framework for efficiency calculations in multistage sampling, with focus on what is sometimes referred to as ascertainment sampling. A method for correcting for the sampling scheme in analysis of ascertainment samples is also presented. Simulation based methods are used to overcome computational issues in both efficiency calculations and analysis of data.

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