Regulation of intracellular signaling events that modulate insulin action

Author: Silvia Gogg; Göteborgs Universitet.; University Of Gothenburg.; [2002]

Keywords: MEDICIN; MEDICINE; insulin; insulin resistance; EGF; Gab 1; insulin receptor substrate; PI3-kinase; Thiazolidinediones; PPARã; insulin signaling; glucose transport; adipose tissue; â-cell.;

Abstract: Insulin regulates several mechanisms of fundamental importance to the body involving glucose, fat andprotein metabolism. Insulin resistance in skeletal muscle, liver and adipose tissue promotes an increaseddemand for insulin secretion. In individuals genetically predisposed to develop type 2 diabetes, thepancreatic

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