Search for dissertations about: "? cell survival"

Showing result 1 - 5 of 1392 swedish dissertations containing the words ? cell survival.

  2. 1. Regulation of Mast Cell Survival

    Author : Christine Möller; Gunnar Nilsson; Alf Grandien; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; mast cell; A1; Bfl-1; Bim; Bcl-2 family members; basophil; SCF; forkhead; survival; Patologi; Pathology; Patologi;

    Abstract : Mast cells are long-lived effector cells of importance for both acute and chronic inflammations. Mast cells can be activated in many different ways, leading to the release of inflammatory mediators. In contrast to most other inflammatory cells, activated mast cells have the capacity to recover, regranulate and thereby be activated again. READ MORE

  4. 2. Molecular Studies of Mast Cell Migration and Apoptosis : Two Ways of Regulating Mast Cell Numbers at Sites of Inflammation

    Author : Jessica Alfredsson; Gunnar Nilsson; Hans-Uwe Simon; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; mast cell; SCF; IL-3; FcεRI; migration; apoptosis; Bim; Bcl-2; Bcl-XL; Akt; FOXO; MAPK; Patologi; Pathology; Patologi;

    Abstract : Upon activation mast cells release numerous proinflammatory mediators. With this feature, mast cells play an important role in host defense against pathogens, and are involved in tissue remodeling and wound healing. However, in cases of excessive inflammation the effects of mast cells are detrimental. READ MORE

  5. 3. In vitro Studies of β-cell Death and Survival. Modulation by Adenoviral Vectors and Bcl-2 Overexpression

    Author : Andreea Roxana Barbu; Nils Welsh; Decio Eiziric; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cell; cytokine; mitochondrial membrane potential; Bcl-2; Adenoviral vector; Adenovirus; IFN-α; Diabetes; Cellbiologi; Cell biology; Cellbiologi;

    Abstract : Type 1 diabetes is a multifactorial disease resulting from the selective destruction of insulin-producing β-cells within the pancreatic islets of Langerhans. The mechanisms of β-cell death are not fully understood but cytokines are important mediators of this process. READ MORE

  6. 4. Cell therapy for denervated tissue

    Author : Roine El-Habta; Ludvig J. Backman; Paul J. Kingham; Patrik Danielson; António Salgado; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue-derived stem cell; cell therapy; denervation; differentiation; myoblast; peripheral nerve injury; proliferation; regeneration; skeletal muscle; stromal vascular fraction; survival; tendon; cellforskning; cell research; Medical Cell Biology; medicinsk cellbiologi;

    Abstract : Background: Peripheral nerve injury results in denervation of tendons and muscles. The biology of denervated muscle has been well studied but little is known about the associated tendons. READ MORE

  7. 5. Adhesion Dependent Signals : Cell Survival, Receptor Crosstalk and Mechanostimulation

    Author : Anjum Riaz; Staffan Johansson; Bengt Hallberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Integrins; Signal transduction; Protein kinase B; Akt; PI3K; Heparanase; ROS; Mechanosignalling; Molekylär cellbiologi; Molecular Cellbiology; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Cellforskning; Cell Research;

    Abstract : The integrin family of cell surface receptors is evolutionary conserved and found in all multicellular animals. In humans 8-alpha and 18-beta integrins are non-covalently associated into 24 dimers. Integrins mediate cell-extracellular matrix and cell-cell interactions and participate in cell signalling. READ MORE