Search for dissertations about: "?H2AX"

Showing result 1 - 5 of 14 swedish dissertations containing the word ?H2AX.

  2. 1. The Importance of Dosimetry and Radiobiology in Nuclear Medicine : Quantitative methods and modelling

    Author : Anna Stenvall; Lund Medicinsk strålningsfysik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Nuclear medicine; radionuclide therapy; radiopharmaceutical therapy; dosimetry; Monte Carlo modelling; radiobiology; ; γH2AX; DOTA-TATE; PET; SPECT;

    Abstract : Nuclear medicine uses radioactive pharmaceuticals for diagnostic or therapeutic purposes. The ionizing radiation emitted from the radiopharmaceutical is partially absorbed within the patient's body and internal dosimetry is the method to estimate the absorbed dose to a tumour or risk organ. READ MORE

  4. 2. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy : Evidence of a preserved low-dose hypersensitivity response

    Author : Fredrik Qvarnström; Ingela Turesson; Gunilla Enblad; Mats Harms-Ringdahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; γH2AX; 53BP1; checkpoint; p21; apoptosis; mitosis; Oncology; Onkologi; Oncology; onkologi;

    Abstract : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. READ MORE

  5. 3. Small-Scale Dosimetry for the Testis: Applications in Nuclear Medicine Diagnostics and Therapy

    Author : Suaad Meerkhan; Lund Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Testis; 111-In; Autoradiography; Biodistribution; Small-Scale; Monte Carlo; Dosimetry; spermatogonia; gammaH2AX; immunofluorescence;

    Abstract : It is well known that the testicles are among the most radiosensitive tissue, and constitute an important critical target for both external and internal radiation during diagnostic and therapeutic use of radionuclides. In systemic radionuclide therapy where very high activities are administered, the testis may become a dose-limiting organ; often with a complex, non-uniform activity distribution and a resulting non-uniform absorbed-dose distribution. READ MORE

  6. 4. WRAP53β and scaRNA2 on their journey to repair the DNA

    Author : Christos Coucoravas; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : WRAP53β is a multifunctional protein involved in several cellular processes like Cajal body formation, telomere maintenance and DNA repair. WRAP53β is responsible for targeting factors to specific cellular locations, and its very high affinity for the scaRNAs could implicate these molecules in similar biological functions. READ MORE

  7. 5. Unwrapping the role of WRAP53β in DNA damage response

    Author : Hanif Rassoolzadeh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal body-specific (sca) RNAs and the telomerase enzyme to Cajal bodies, as well as targeting of the E3 ligase RNF8 to DNA double-strand breaks (DSBs). READ MORE