Search for dissertations about: "[11C]verapamil"

Found 1 swedish dissertation containing the word [11C]verapamil.

  1. 1. Blood-Brain Barrier Transport Investigation of Active Efflux using Positron Emission Tomography and Modelling Studies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Stina Syvänen; Uppsala universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; pharmacokinetics; P-glycoprotein; blood-brain barrier; modelling; PET; active efflux; species differences; [11C]verapamil; drug development; Farmaceutisk biovetenskap;

    Abstract : This thesis examines the transport of exogenous molecules across the blood-brain barrier (BBB), focusing on active efflux, using positron emission tomography (PET), computer simulation and modelling. P-glycoprotein (P-gp) inhibition was studied using [11C]verapamil and [11C]hydroxyurea was investigated as a new marker for active efflux transport. READ MORE