Search for dissertations about: "Örjan Carlborg"

Found 5 swedish dissertations containing the words Örjan Carlborg.

2. 1. Complex Trait Genetics : Beyond Additivity

   Author : Simon Forsberg; Örjan Carlborg; Julien Ayroles; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; genetic interactions; epistasis; additivity; GWAS; vGWAS; Genetic mapping; yeast; Arabidopsis Thaliana; dog; Genetik; Genetics;

   Abstract : The link between the genotype and the phenotype of an organism is immensely complex. Despite this it can, to a great extent, be captured using models that assume that gene variants combine their effects in an additive manner. This thesis explores aspects of genetics that cannot be fully captured using such additive models. READ MORE

4. 2. Numerical Algorithms for Mapping of Multiple Quantitative Trait Loci in Experimental Populations

   Author : Kajsa Ljungberg; Sverker Holmgren; Örjan Carlborg; Margot Gerritsen; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Scientific computing; Beräkningsvetenskap; Scientific Computing;

   Abstract : Most traits of medical or economic importance are quantitative, i.e. they can be measured on a continuous scale. Strong biological evidence indicates that quantitative traits are governed by a complex interplay between the environment and multiple quantitative trait loci, QTL, in the genome. READ MORE

5. 3. The impact of selection on the genetic architecture of complex traits

   Author : Tilman Rönneburg; Örjan Carlborg; Dirk-Jan De Koning; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biologi med inriktning mot populationsbiologi; Biology with specialization in Population Biology; Bioinformatik; Bioinformatics;

   Abstract : Accurate dissection of highly polygenic traits is difficult, in part due to the power required to identify and characterise minor loci, but also due to the potential nonadditive interactions between the contributing genetic variations within a population. This is often further complicated by the genetic features of natural or agricultural populations, where a good understanding of the genetic architecture of a quantitative trait, e. READ MORE

6. 4. Novel Statistical Methods in Quantitative Genetics : Modeling Genetic Variance for Quantitative Trait Loci Mapping and Genomic Evaluation

   Author : Xia Shen; Örjan Carlborg; Lars Rönnegård; William Hill; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; statistical genetics; quantitative trait loci; genome-wide association study; genomic selection; genetic variance; hierarchical generalized linear model; linear mixed model; random effect; heteroscedastic effects model; variance-controlling genes; Complex Systems – Microdata Analysis;

   Abstract : This thesis develops and evaluates statistical methods for different types of genetic analyses, including quantitative trait loci (QTL) analysis, genome-wide association study (GWAS), and genomic evaluation. The main contribution of the thesis is to provide novel insights in modeling genetic variance, especially via random effects models. READ MORE

7. 5. Understanding the genetic basis of complex traits

   Author : Yanjun Zan; Örjan Carlborg; Pär Ingvarsson; Uppsala universitet; []
   Keywords : genetic architecture; complex traits; epistasis; multi-allelic; genotype by environment interaction; polygenic adaptation; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

   Abstract : Recent advances in genetics and genomics have provided numerous opportunities to study the genetic basis of complex traits. Nevertheless, dissecting the genetic basis of complex traits is still challenged by the complex genetic architecture, in which many genes are involved, and many have small contributions to phenotypic variation, interactions with other genes or environmental factors. READ MORE