Search for dissertations about: "β-cell"

Showing result 1 - 5 of 116 swedish dissertations containing the word β-cell.

  2. 1. Epac2 signaling at the β-cell plasma membrane

    Author : Ida Alenkvist; Anders Tengholm; Olga Göransson; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-cell; insulin secretion; cAMP; Ca2 ; Epac; Rap; exocytosis; sulfonylurea; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Secretion of appropriate amounts of insulin from pancreatic β-cells is crucial for glucose homeostasis. The β-cells release insulin in response to glucose and other nutrients, hormones and neurotransmitters, which trigger intracellular signaling cascades, that result in exocytotic fusion of insulin-containing vesicles with the plasma membrane. READ MORE

  4. 2. Diabetes in Young Adults : Remission, β-cell function and markers of inflammation

    Author : Anna Schölin; Elisabeth Björk; Anders Karlsson; Jan Åman; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Internal medicine; type 1 diabetes; young adults; remission; β-cell function; islet antibodies; gender; CRP; Invärtesmedicin; Internal medicine; Invärtesmedicin; Internal Medicine; invärtesmedicin;

    Abstract : Type 1 diabetes is caused by immuno-mediated β-cell destruction leading to insulin deficiency and hyperglycaemia. The decline in β-cell function and the clinical course after diagnosis vary. Whether the process of destruction of the β-cells is associated with markers of a non-specific inflammatory response is unknown. READ MORE

  5. 3. Search for molecular and metabolic mechanisms contributing to impaired β-cell function

    Author : Siri Malmgren; Diabetes - epigenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-1α; oxygen consumption; β-cell; Insulin secretion; Type 2 Diabetes; mitochondrial metabolism; metabolic profiling; Lipotoxicity; Histone acetylation; Histone methylation;

    Abstract : Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. READ MORE

  6. 4. β-cell dysfunction in Huntington's disease

    Author : Karl Bacos; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolism; secretion; Insulin; trafficking; R6 2 mouse; granule; exocytosis; neurodegeneration; huntingtin;

    Abstract : Huntington's disease (HD), a fatal neurodegenerative disorder, is associated with an increased risk of diabetes mellitus. The reason for this is unknown, but considering the functional similarities of neurons and the insulin secreting pancreatic β-cell, pathological mechanisms may be shared by both cell types and account for neuronal as well as endocrine dysfunction. READ MORE

  7. 5. Neogenesis and alloxan toxicity in pancreatic islets, with special reference to the transplanted human β-cell

    Author : Björn Tyrberg; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Alloxan; β-cell; diabetes; differentiation; growth; insulin secretion; nephrectomy; ob ob; pancreatic islet; transplantation; guinea-pig human; mouse; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The aim of this work was to study whether adult human pancreatic β-cells have the capacity to proliferate in culture and after transplantation to the renal subcapsular space of mice. An immunosuppressive regimen for human islet discordant xenotransplantation to mice was designed. READ MORE