Search for dissertations about: "β-cell"
Showing result 11 - 15 of 118 swedish dissertations containing the word β-cell.
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11. On macrophage contributions to tissue homeostasis : New insights on pancreas development and healing of ischemic injury
Abstract : Besides providing host defence against innumerable threats, macrophages display additional key functions for preservation of tissue homeostasis. This thesis includes four studies that explore novel macrophage functions in both the development of islets of Langerhans and healing of ischemic injury in mice. READ MORE
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12. The Best Leading Role for Maintaining Normal β-cell Function Goes to MafA and Voltage-gated Calcium Channel Subunit γ4
Abstract : .... READ MORE
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13. The impact of glucotoxicity on pancreatic β-cell function
Abstract : Type 2 diabetes mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. READ MORE
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14. ADP regulation of insulin secretion and beta-cell apoptosis
Abstract : The aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 and P2Y13 were shown in both mouse pancreatic islets and isolated β-cells using real-time PCR quantification. READ MORE
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15. Membrane lipids and their transfer proteins in β-cells
Abstract : Insulin secretion from β-cells is essential for glucose homeostasis and is often dysregulated in diabetes. Intracellular Ca2+ and membrane lipids cooperate to control insulin secretion with high spatial and temporal precision. READ MORE