Search for dissertations about: "β-lactam"
Showing result 1 - 5 of 26 swedish dissertations containing the word β-lactam.
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1. Neurotoxicity of β-lactam antibiotics : experimental kinetic and neurophysiological studies
Abstract : The neurotoxic potential of intravenous administered benzylpenicillin (BPC) was studied in rabbits with intact blood-CNS barriers and rabbits with experimental E. coli meningitis. At onset of epileptogenic EEG activity or seizures, serum, CSF and brain tissue were collected for assay of BPC. READ MORE
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2. Antibacterial Effect and Inflammatory Response in Relation to Antibiotic Treatment of Sepsis
Abstract : Sepsis defines as life-threatening organ dysfunction caused by a dysregulated host response to infection. The importance of early administration of antibiotics in septic shock is undisputed, but the optimal antibiotic choice remains uncertain. READ MORE
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3. Prognostic assessment in community acquired pneumonia
Abstract : Community acquired pneumonia (CAP) is the most commonly occurring infectious disease that requires hospital admission. CAP affects mainly, the youngest, the oldest, the poorest and the sickest. Annual incidence is 5-12 per 1000 adults. Between 20% and 40% of patients with CAP need in-hospital treatment. READ MORE
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4. Synthesis and biological evaluation of Bicyclic β-Lactams and 2-Pyridinones : Pilicides Targeting Pilus Biogenesis in Pathogenic Bacteria
Abstract : New methods have been developed for the synthesis of bicyclic β-lactams and 2-pyridinones by combining acyl Meldrum’s acids and Δ2-thiazolines. The 2-pyridinones were synthesised both in solution using conventional heating or microwave assisted heating as well as by solid supported chemistry. READ MORE
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5. Chromosomal β-lactamases in enterobacteria and in vivo evolution of β-lactam resistance
Abstract : The ß-lactam antibiotics are the most important antibacterial agents in the treatment of infectious diseases. A severe problem in ß-lactam therapy is the emergence of ß-lactam resistant bacteria. Clinical ß-lactam resistance is most often due to the production of ß-lactamases. ß-lactamase genes reside either on plasmids or on the chromosome. READ MORE