Search for dissertations about: "β-lactam"

Showing result 11 - 15 of 26 swedish dissertations containing the word β-lactam.

  2. 11. Development of phosphorus-containing metallo-β-lactamase inhibitors : Synthesis and binding studies by solution NMR and molecular docking

    Author : Katarzyna Palica; Máté Erdélyi; Christopher J. Schofield; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MBL inhibitors; antibiotic resistance; metallo-β-lactamases; NMR spectroscopy; Medicinal Chemistry; Läkemedelskemi;

    Abstract : The rapidly growing bacterial resistance development is turning into one of the main challenges of the 21st century. Our antibiotics are becoming ineffective for the treatment of bacterial infections, and without successful action, simple infections, such as pneumonia or Septicemia, will soon carry a highly probable mortal prognosis. READ MORE

  4. 12. Dynamics and Mechanisms of Adaptive Evolution in Bacteria

    Author : Song Sun; Dan Andersson; Diarmaid Hughes; Josep Casadesús; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; adaptive evolution; mutation; genome rearrangements; antibiotic resistance; gene amplification; genome reduction; directed evolution; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Abstract : Determining the properties of mutations is fundamental to understanding the mechanisms of adaptive evolution. The major goal of this thesis is to investigate the mechanisms of bacterial adaptation to new environments using experimental evolution. READ MORE

  5. 13. Cell wall remodeling proteins in Mycobacterium tuberculosis : structure, function and inhibition

    Author : Eva Maria Rebrova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The complex and peculiar cell wall architecture is vital for the survival of M. tuberculosis in the host and therefore an established target for several currently used drugs. READ MORE

  6. 14. Invasive disease by Haemophilus influenzae in Sweden in the era of the H. influenzae type b vaccine

    Author : Fredrik Resman; Enheten för infektionssjukdomar; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haemophilus influenzae; sepsis; epidemiology; antimicrobial resistance; bacterial adhesion;

    Abstract : What is the current status of Haemophilus influenzae as an agent of invasive infection in Sweden? H. influenzae type b (Hib) used to be a common cause of meningitis, epiglottitis and severe sepsis in young children. READ MORE

  7. 15. Plasmid mediated antibiotic resistance : with focus on extended spectrum β-lactamases (ESBL)

    Author : Alma Brolund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Enterobacteriaceae is a family of bacteria including Escherichia coli and Klebsiella pneumoniae that are common colonizers of the gastrointestinal tract. Extended spectrum β- lactamases (ESBL) are bacterial enzymes that degrade β-lactam antibiotics and thus make the bacteria resistant to β-lactam antibiotics. READ MORE