Search for dissertations about: "β-lactamase"

Showing result 1 - 5 of 24 swedish dissertations containing the word β-lactamase.

  1. 1. Epidemiology of extended-spectrum β-lactamase-producing Escherichia coli

    Author : Sofia Ny; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Extended-Spectrum β-Lactamase and plasmid mediated AmpC (ESBL/pAmpC)-producing Escherichia coli (E. coli) has during the last decades emerged worldwide and is now an increasing problem in both human and animal health. READ MORE

  2. 2. Long-term molecular epidemiology of extended-spectrum β-lactamase producing Escherichia coli in a low-endemic setting

    Author : Anna Fagerström; Bo Söderquist; Paula Mölling; Martin Sundqvist; Katarina Persson; Linus Sandegren; Örebro universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Escherichia coli; extended-spectrum β-lactamase; whole genome sequencing; plasmids; hybrid assembly; environment; IncI1; ST131;

    Abstract : Escherichia coli is a commensal inhabitant in the gastro-intestinal tract of humans and animals but it is also the most common bacterial species causing urinary tract infection, which ranges in severity from distal cystitis to urosepsis and septic shock. During the past decades, the prevalence of antibiotic resistant E. READ MORE

  3. 3. On bacterial formats in protein library technology

    Author : Per-Åke Löfdahl; Per-Åke Nygren; Mikael Widersten; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; Affibody molecule; β-lactamase; combinatorial library; green fluorescent protein GFP ; protein engineering; protein fragment complementation assay PCA ; selection; TEVprotease; TNF-α; Bioengineering; Bioteknik; Enzyme engineering; Enzymteknik;

    Abstract : Millions of years of evolution have resulted in an immense number of different proteins, which participate in virtually every process within cells and thus are of utmost importance for allknown forms of life. In addition, there are several examples of natural proteins which have found use in applications outside their natural environment, such as the use of enzymes infood industry and washing powders or the use of antibodies in diagnostic, bioseparation or therapeutic applications. READ MORE

  4. 4. Multi-Resistance Plasmids : Fitness Costs, Dynamics and Evolution

    Author : Fredrika Rajer; Linus Sandegren; Pål Jarle Johnsen; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; multi-resistance plasmids; evolution; fitness cost; dynamics; escherichia coli; ESBL; gene amplification; β-lactamase inhibitor; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Abstract : Antibiotic resistance is an escalating problem, not only due to less desirable treatment options and outcome, but also due to the economic burden to health care caused by resistant pathogens. Since the process of developing new antibiotics is slow, we need to carefully consider the usage of the antibiotics still available. READ MORE

  5. 5. Burden of disease and identification of intervention targets in extended-spectrum β-lactamase-associated infections

    Author : Joakim Isendahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Extended-spectrum β-lactamase-producing Enterobacteriaceae (EPE) have surged globally since the early 2000s, partly due to dissemination of CTX-M-15 producing Escherichia coli (E. coli) sequence type 131 and its sub-lineages H30-R and H30-Rx. READ MORE