Search for dissertations about: "β-lactamase"

Showing result 6 - 10 of 29 swedish dissertations containing the word β-lactamase.

2. 6. Burden of disease and identification of intervention targets in extended-spectrum β-lactamase-associated infections

   Author : Joakim Isendahl; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Extended-spectrum β-lactamase-producing Enterobacteriaceae (EPE) have surged globally since the early 2000s, partly due to dissemination of CTX-M-15 producing Escherichia coli (E. coli) sequence type 131 and its sub-lineages H30-R and H30-Rx. READ MORE

4. 7. Clinical Impact of Bloodstream Infections – Characterization, Risk factors and Outcome

   Author : Martin Holmbom; Håkan Hanberger; Christian G. Giske; Lennart E Nilsson; Mats Fredrikson; Åse Östholm Balkhed; Ralph Peeker; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bloodstream infection BSI ; Antimicrobial resistance AMR ; Extended spectrum β-lactamase ESBL ; ESBL-producing Enterobacterales; Multidrug-resistant; Urinary tract infection; Sepsis; Epidemiology; Prehospital delay; Community-acquired BSI; Hospital-acquired BSI; Community-onset BSI;

   Abstract : Bloodstream infection (blood poisoning) and antibiotic resistance are increasing worldwide, and already cause the loss of millions of human lives each year. According to the World Health Organisation (WHO), bloodstream infections (BSIs) represent 20% of global mortality on a par with cardiac infarct, stroke, and major trauma. READ MORE

5. 8. Phosphonamidates as potential NDM-1 inhibitors

   Author : Katarzyna Palica; Mate Erdelyi; Lindon Moodie; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : WHO’s recent reports indicate that the rapidly growing resistance of bacteria became one of the biggest problems of the XXI century. The most powerful human counter weapon, antibiotics, starts to become ineffective for the treatment of bacterial infections. READ MORE

6. 9. Bacterial Outer Membrane Vesicles. Mediators of virulence and antibiotic resistance

   Author : Viveka Schaar; Malmö Klinisk mikrobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; Moraxella catarrhalis; epithelial cells; beta-lactamase; non-typeable Haemophilus influenzae; outer membrane vesicles; polymicrobial infections; UspA1;

   Abstract : Outer membrane vesicles (OMV) have the size of nanoparticles and are released from the outer membrane of most Gram-negative bacteria. The OMV reflect the composition of the bacterial outer membrane, including lipids and virulence factors specific for the pathogen, and are involved in pathogenesis and bacterial survival. READ MORE

7. 10. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development

   Author : Lisa Allander; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Arnfinn Sundsfjord; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria; antibiotic combination therapy; antibiotic resistance; beta-lactams; beta-lactamase inhibitors; Infektionssjukdomar; Infectious Diseases;

   Abstract : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. READ MORE