Search for dissertations about: "β-lactamases"

Showing result 1 - 5 of 8 swedish dissertations containing the word β-lactamases.

  1. 1. New antibiotic resistance genes and their diversity

    University dissertation from Gothenburg : Chalmers tekniska högskola

    Author : Fanny Berglund; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metagenomics; β-lactamases; hidden Markov model; antibiotic resistance; carbapenemases; big data; tetracycline resistance;

    Abstract : Antibiotic resistance is increasing worldwide and is considered a severe threat to public health. Often, antibiotic resistance is caused by antibiotic resistance genes, of which many are hypothesized to have been transferred into human pathogens from environmental bacteria. READ MORE

  2. 2. Plasmid mediated antibiotic resistance : with focus on extended spectrum β-lactamases (ESBL)

    University dissertation from Stockholm : Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology

    Author : Alma Brolund; Karolinska Institutet.; Karolinska Institutet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Enterobacteriaceae is a family of bacteria including Escherichia coli and Klebsiella pneumoniae that are common colonizers of the gastrointestinal tract. Extended spectrum β- lactamases (ESBL) are bacterial enzymes that degrade β-lactam antibiotics and thus make the bacteria resistant to β-lactam antibiotics. READ MORE

  3. 3. Chromosomal β-lactamases in enterobacteria and in vivo evolution of β-lactam resistance

    University dissertation from Stockholm : Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology

    Author : Sven Bergström; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram negative bacteria; ß-lactamase genes; divergence of neighbouring cperons; ß-lactamase hyperproduction; evolution of control sequences;

    Abstract : The ß-lactam antibiotics are the most important antibacterial agents in the treatment of infectious diseases. A severe problem in ß-lactam therapy is the emergence of ß-lactam resistant bacteria. Clinical ß-lactam resistance is most often due to the production of ß-lactamases. ß-lactamase genes reside either on plasmids or on the chromosome. READ MORE

  4. 4. Mechanisms and Dynamics of Carbapenem Resistance in Escherichiacoli

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Marlen Adler; Linus Sandegren; Josep Casadesús; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; carbapenem; antibiotic resistance; fitness cost; ESBLs; penicillin-binding proteins; gene amplification;

    Abstract : The emergence of extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae worldwide has led to an increased use of carbapenems and may drive the development of carbapenem resistance. Existing mechanisms are mainly due to acquired carbapenemases or the combination of ESBL-production and reduced outer membrane permeability. READ MORE

  5. 5. A world inside Gastrointestinal microbiota in healthy Swedish children at day care centers and aspects on antibiotic resistance, enteric pathogens and transmission

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johan Kaarme; Tryggve Nevéus; Björn Olsen; Jonas Ludvigsson; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ESBL; VRE; enteropathogens; antibiotic resistance; children; preschool; Pediatrik; Pediatrics;

    Abstract : Antibiotic resistance is a growing threat to human health and is defined by the World Health Organization as a crisis that must be managed with the utmost urgency. Antibiotic resistant bacteria increase both mortality and morbidity and have a great impact on the global economy. READ MORE