Search for dissertations about: "γ-secretase"

Showing result 1 - 5 of 23 swedish dissertations containing the word γ-secretase.

  2. 1. Notch Signaling in Neuroblastoma and Renal Cell Carcinoma

    Author : Jonas Sjölund; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; differentiation; clear cell renal cell carcinoma; neuroblastoma; TGF-beta; migration; γ-secretase; valproic acid; cancer; Notch; ERK; von Hippel-Lindau; hypoxia;

    Abstract : The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. READ MORE

  4. 2. Molecular studies of the γ-secretase complex : focus on genetic and pharmacological modulation

    Author : Johanna Wanngren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : γ-Secretase is a multi-subunit protease complex, composed of presenilin (PS1 or PS2), Nicastrin, Pen-2 and Aph-1, which generates the Alzheimer disease (AD) related 30-43 amino acid long amyloid β-peptide (Aβ). The complex is also crucial for important cell signaling, such as the Notch receptor pathway. READ MORE

  5. 3. Different types of γ-secretes complexes and their effect on substrate processing

    Author : Annelie Pamrén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The γ-secretase complex is a transmembrane aspartyl protease that generates the Alzheimer disease (AD) related amyloid β-peptide (Aβ) from the amyloid precursor protein (APP). The γ-secretase complex cleaves APP at two different sites (γ- and ε-sites) generating Aβ-peptides and the APP intracellular domain (AICD). READ MORE

  6. 4. Identification and investigation of gamma-secretase associated proteins from brain

    Author : Yasuhiro Teranishi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. The pathological hallmarks in the AD brain are extracellular deposition of amyloid plaques, mainly composed of the amyloid β-peptide (Aβ), and intracellular neurofibrillary tangles made of hyperphosphorylated tau. READ MORE

  7. 5. The amyloid-β precursor protein (APP)-binding protein Fe65 and APP processing

    Author : Niina Koistinen; Anna-Lena Ström; Stefan Kins; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; APP; Fe65; ADAM10; Alzheimer s disease; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by abnormal deposition of neurotoxic amyloid-β (Aβ) peptide. Aβ is generated by sequential cleavage of the amyloid-β precursor protein (APP) by β- and then γ-secretase. READ MORE