Search for dissertations about: "γ-turn mimetic"

Found 2 swedish dissertations containing the words γ-turn mimetic.

  1. 1. Design and Synthesis of AT2 Receptor Selective Angiotensin II Analogues Encompassing β- and γ-Turn Mimetics

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ulrika Rosenström; Anders Hallberg; Stephen Hanessian; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Angiotensin II; AT2; AT1; Benzodiazepine; Peptidomimetics; γ-turn; β-turn; Farmaceutisk kemi; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi;

    Abstract : Important information on the bioactive conformation of biologically active peptides may be obtained by studies of rigid peptides or well-defined secondary structure mimetics incorporated into pseudopeptides. The structural requirements for the interaction of angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) with its AT1 and AT2 receptors were the subject of this study. READ MORE

  2. 2. Design and Synthesis of Angiotensin IV Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP)

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hanna Andersson; Anders Hallberg; Anders Karlén; Federico Corelli; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiotensin IV; AT4; insulin-regulated aminopeptidase IRAP ; inhibitor; peptidomimetics; γ-turn mimetic; macrocycle; NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry; NATURVETENSKAP Kemi Organisk kemi Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Peptidomimetics derived from the bioactive hexapeptide angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) have been designed and synthesized. These peptidomimetics are aimed at inhibiting the insulin-regulated amino peptidase (IRAP), also known as the AT4 receptor. READ MORE