Search for dissertations about: "1.4 addition"

Showing result 11 - 15 of 135 swedish dissertations containing the words 1.4 addition.

  2. 11. Synthetic development towards benzodiazepine alkaloids : total synthesis of circumdatin F and C

    Author : Anette Witt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alkaloids; benzodiazepines; cyclisation; Michael reactions; quinazolinones; synthesis.;

    Abstract : Benzodiazepine alkaloids exhibit a multitude of interesting pharmacological activities. This thesis deals with the development of synthetic methods towards such alkaloids, of which the main efforts can be divided into three parts. READ MORE

  4. 12. Organomolybdenum Complexes in Organic Synthesis- New methods for the Preparation of Cationic Diene Complexes and Applications to Synthesis

    Author : Emelie Bjurling; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; indoles; carbenium ions; hexafluoroisopropanol; hydride abstraction; molybdenum; cationic diene complexes;

    Abstract : Indolyl substituted pyranyl- and cyclohexenyl molybdenum complexes were synthesised through stereoselective nucleophilic addition of indoles to the corresponding cationic 2H-pyran or cyclohexadiene molybdenum complex. Decomplexation of an allylic molybdneum complex by treatment with iodine gave 1-(4-iodo-2-cyclohexenyl)-1H-indole-3-carbonitrile in high regio-selectivity. READ MORE

  5. 13. Transcriptional regulation of the neuropeptide galanin : special reference to axotomy

    Author : Jacqueline D Corness; Karolinska Institutet; Karolinska Institutet; []
    Keywords : galanin; axotomy; nerve injury; neuropeptide; leukaemia inhibiting factor; transcription; dorsal root ganglion; nerve growth factor;

    Abstract : Galanin is a neuropeptide which is located in both the central and peripheral nervous system. In peripheral neurones, this peptide is thought to be involved in influencing pain sensation after nerve injury (neuropathic pain) and also in the regeneration of peripheral nerves. READ MORE

  6. 14. Development of new Catalytic Methods for the Selective Synthesis of Heterocycles

    Author : Stalin Reddy Pathi Pati; Nicklas Selander; Masaharu Nakamura; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; catalysis; indium; heterocycles; Lewis acid; multicomponent reactions; furans; alkynes; organisk kemi; Organic Chemistry;

    Abstract : In the field of organic chemistry, the development of new catalytic methods for the synthesis of complex molecules from simple precursors is a top priority. The main focus of this thesis concerns the diastereoselective synthesis of heterocyclic compounds using main group elements as Lewis acid catalysts. READ MORE

  7. 15. Development of Asymmetric Iridium Catalysed Hydrogenation Reactions

    Author : Suppachai Krajangsri; Pher Andersson; Patrick Guiry; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Asymmetric hydrogenation; Iridium catalyst; Peterson olefination; Dynamic Kinetic Resolution; organisk kemi; Organic Chemistry;

    Abstract : The focus of the work presented in this thesis is the development of iridium-catalysed asymmetric hydrogenation reactions.The first part of this thesis covers the development of dynamic kinetic resolution in asymmetric hydrogenation of chiral, racemic secondary allylic alcohols, which are converted to chiral saturated alcohols with high dr and ee. READ MORE