Search for dissertations about: "11 beta-HSD"

Found 5 swedish dissertations containing the words 11 beta-HSD.

  2. 1. Glucocorticoid administration : studies on weight regulation and metabolic implications

    Author : Joanna Uddén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glucocorticoids; leptin; obesity; adipose tissue; PAI-1; UCP-2; cortisol; the metabolic syndrome; 11 beta-HSD; eating behaviour; weight gain.;

    Abstract : Long-term treatment with glucocorticoids induces weight gain and increased risk to develop obesity-related metabolic complications like insulin resistance, type 2 diabetes and cardiovascular disease. Glucocorticoids have been suggested to play a role in development of visceral fat accumulation. READ MORE

  4. 2. Expression and purification of membrane proteins: Focus on the G-protein coupled receptor MC4r

    Author : Viveka Dolby; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; enzymology; Proteiner; enzymologi; Proteins; melanocortin 4 receptor; GPCR; purification; Expression; membrane proteins;

    Abstract : Membrane proteins are crucial components of the cell and are involved in many biological processes. Recombinant overexpression systems together with different purification methods are necessary to obtain large amounts of purified receptor for biophysical and functional studies. READ MORE

  5. 3. Increased glucocorticoid sensitivity in pancreatic beta-cells : effects on glucose metabolism and insulin release

    Author : Behrous Davani; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glucocorticoids; glucocorticoid receptor; Pancreatic beta-cell; Type 2 diabetes; insulin release;

    Abstract : Type 2 diabetes mellitus (T2DM) is characterized by three pathological alterations: (1) insulin resistance in peripheral tissues, (2) increased hepatic glucose production and (3) impaired insulin secretion from the pancreatic beta-cells. Glucocorticoids (GCs) exert profound effects on glucose homeostasis. READ MORE

  6. 4. The metabolic syndrome : studies on thrifty genes

    Author : Katja Kannisto; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adipose tissue; adiponectin; 11beta-hydroxysteroid dehydrogenase type 1; BMI; glucocorticoid; GLUT; HAART; HIV; IL-6; insulin; insulin resistance; LDL-cholesterol; leptin; lifestyle; lipodystrophy; LPL; obesity; PPAR; PGC-1; polymorphism; rosiglitazone; skeletal muscle; twins;

    Abstract : The metabolic syndrome consists of a cluster of atherogenic risk factors that include insulin resistance, glucose intolerance, hyperglycemia, dyslipidemia, obesity and a procoagulant state with impaired fibrinolysis. Genetic factors might predispose to the metabolic syndrome while the increasing prevalence of visceral and abdominal obesity linked to the shift to more sedentary lifestyles exacerbates the manifestation. READ MORE

  7. 5. Congenital adrenal hyperplasia, CYP21 deficiency, screening and clinical aspects

    Author : Anna Nordenström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Congenital adrenal hyperplasia; 21 -hydroxylase deficiency; CYP21; neonatal screening; 17-OHP; sex-typed behavior; toy play.;

    Abstract : Congenital adrenal hyperplasia (CAH) is a group of recessively inherited disorders. More than 90% of all cases of CAB are caused by 21-hydroxylase deficiency. This enzyme deficiency results in reduced ability to synthesize cortisol and aldosterone and at the same time increased secretion of androgens. READ MORE